Analysis of age-related variations in laboratory tests by use of latent information recovered from routine laboratory data

利用从常规实验室数据中恢复的潜在信息分析实验室测试中与年龄相关的变化

• 批准号: 13672437
• 负责人: ICHIHARA Kiyoshi
• 金额: $ 1.15万
• 依托单位: Yamaguchi University (2002)Kawasaki Medical School (2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672437/
• 关键词: reference interval; disease-specific reference interval; age-related changes; latent reference value extraction method; data-mining; latent abnormal value exclusion method; standardization; 小児基準値; フタマイニング; 臨床検査; 基準個体; 多変量解析

I have developed a data-mining method to derive a reference interval (RI) for laboratory tests from a routine laboratory data, called "latent reference value extraction method", in 1996. It features simultaneous setting of RIs for multiple test items mutually related and a rigid exclusion of those individuals with abnormal values in other test items. Thus it requires an iterative processing to optimize RIs. In this research I developed a realistic algorithm to obtain appropriate initial estimates of RIs, to exclude apparently abnormal individuals, and to adjust for a distorted age distribution commonly seen in patients' population. A software based on the revised methodology not only has a flexible ability to optimize derivation of RIs but also has an ability to derive age-specific reference interval using a stepwise age-adjusted exclusion of abnormal values. The software was applied to various clinical laboratory data. In Okayama, age-related RIs were derived for common test items. Consistent age-related changes in RIs were observed in all the analytes. It was also applied to reveal year-by-year changes in RIs (0 to 23 year old) for major laboratory analytes. All of them showed peculiar profiles while a use of conventional methodology led to apparently distorted profiles. It was also found to be applicable to obtain so-called disease-specific RIs using a large data from hemodialysis patients.

我开发了一种数据挖掘方法，用于从1996年从常规实验室数据（称为“潜在参考值提取方法”）得出实验室测试的参考间隔（RI）。它具有与其他测试项目中异常值的人相互关联的多个测试项目的RIS设置。因此，它需要迭代处理以优化RIS。在这项研究中，我开发了一种现实的算法，以获得对RI的适当初始估计，排除显然异常的个体，并适应患者人群中常见的年龄分布。基于修订的方法的软件不仅具有优化RI的推导的灵活能力，而且还具有使用逐步通过年龄调整的异常值来推导年龄特定参考间隔的能力。该软件应用于各种临床实验室数据。在冈山，与年龄相关的RI是针对常见测试项目得出的。在所有分析物中都观察到了与年龄相关的一致变化。它还用于揭示主要实验室分析物的RIS（0至23岁）的同比变化。所有这些都显示出奇特的曲线，而传统方法的使用则显然导致了剖面。还发现它适用于使用血液透析患者的大数据获得所谓的特异性RI。

项目成果

Itoh Y., Ichihara K.: "Standardization of immunoassay for CRM 470-relate d proteins in Japan: from evaluating CRM 470 to setting reference intervals."Clin. Chem. Lab. Med.. 39. 1052-1061 (2001)

Itoh Y.、Ichihara K.：“日本 CRM 470 相关 d 蛋白免疫测定的标准化：从评估 CRM 470 到设定参考区间。”

Ichihara, K., Sato, K.: "Evidence-based laboratory interpretation system built on a large collection of case records with well-defined diagnosis"Clin Chem Labo Med.. 39. 1033-1044 (2000)

Ichihara, K.、Sato, K.：“基于大量病例记录并具有明确诊断的基于证据的实验室解释系统”Clin Chem Labo Med.. 39. 1033-1044 (2000)

Itho, Y.Ichihara, K.: "Standardization of immunoassay for CRM 470-related proteins in Japan : from evaluating CRM 470 to setting reference intervals"Clin Chem Labo Med. 39. 1054-1061 (2001)

Itho, Y.Ichihara, K.：“日本 CRM 470 相关蛋白免疫测定的标准化：从评估 CRM 470 到设定参考区间”Clin Chem Labo Med。

Ichihara K. et al.: "Diagnostic and epidemiological implications of regional differences in biochemistry and protein profiles obaerved in six asian cities"Clin Chem Lab Med. Vol40. S323 (2002)

Ichihara K. 等人：“在六个亚洲城市观察到的生物化学和蛋白质谱区域差异的诊断和流行病学意义”Clin Chem Lab Med。

Ichihara K., et al.: "Diagnostic and epidemiological implications of regional differences in biochemistry and protein profiles obaerved in six asian cities"Clin. Chem. Lab. Med.. 40Suppl.. 55 (2002)

Ichihara K. 等人：“在六个亚洲城市观察到的生物化学和蛋白质谱的区域差异的诊断和流行病学意义”Clin。