Development of Novel Sensors Using Macrocyclic Polyamines as Sensory Elements

使用大环多胺作为传感元件的新型传感器的开发

• 批准号: 63840019
• 负责人: UMEZAWA Yoshio
• 金额: $ 7.1万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B).
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63840019/
• 关键词: Macrocyclic Polyamine; Anion-selective Electrode; Adenosine Nucleotide; Dicarboxylic Acid; Potentiometry; Langmuir-Blodgett (LB) Membrane Sensor; Permeability Change; Cyclic Voltammetry; 脂溶性大環状ポリアミン; 分子認識素子; ATP^<4->センサ-; ジカルボン酸陰イオンセンサ-; ボルタンメ

A novel type of chemical sensors were constructed by using macrocyclic polyamines and related compounds as sensory elements. Potentiometric responses and selectivities were investigated and the following results were obtained, demonstrating a remarkable potentiality of this class of hosts as novel sensory elements.(1) The macrocyclic polyamine liquid membrane electrodes showed strong potentiometric responses and marked selectivities for organic anions such as adenosine nucleotides and dicarboxylates. Potentiometric selectivities based on the magnitude of charge or the distance between charges within the guest molecule were observed.(2) These electrodes also showed potentiometric responses to catechol and related compounds that are in the nonionic forms at the experimental pH. A systematic investigation demonstrated proton ejection as a possible mechanism for potentiometric responses to the uncharged molecules.(3) Sapphyrin (expanded porphyrin) and cytosine-pendant triamine were examined as novel sensory elements for anion-selective liquid membrane electrodes.(4) Anion responsive Langmuir-Blodgett (LB) membrane sensors were fabricated with polyamine hosts. Selectivities for organic anions were evaluated on the basis of analyte-induced permeability changes detected by cyclic voltammetry.

利用大环多胺和相关化合物作为传感元件构建了一种新型化学传感器。对电位响应和选择性进行了研究，得到了以下结果，证明了此类宿主作为新型感觉元件的显着潜力。（1）大环多胺液膜电极对腺苷核苷酸等有机阴离子表现出强烈的电位响应和显着的选择性和二羧酸盐。观察到基于客体分子内电荷大小或电荷之间距离的电位选择性。(2) 这些电极还对实验 pH 下非离子形式的儿茶酚和相关化合物表现出电位响应。一项系统研究表明，质子弹射是对不带电分子进行电位反应的一种可能机制。(3) 蓝宝石蛋白（扩张卟啉）和胞嘧啶悬垂三胺作为阴离子选择性液膜电极的新型传感元件进行了研究。(4) 阴离子响应Langmuir-Blodgett (LB) 膜传感器是用聚胺主体制造的。根据循环伏安法检测到的分析物引起的渗透性变化评估有机阴离子的选择性。

项目成果

小田嶋 和徳(共著): "機能性太環状化合物の分析化学への応用" アイピ-シ-, 78 (1990)

Kazunori Odashima（合著者）：“功能性大环化合物在分析化学中的应用”IPPC，78（1990）

M.Kataoka: Anal.Lett.(1989)

M.Kataoka：肛门快报（1989）

Y.Umezawa: "Ion-Selective Electrodes 5" Akademiai Kiado and Elsevier, (1989)

Y.Umezawa：“离子选择电极 5”Akademiai Kiado 和 Elsevier，(1989)

K.Odashima(共著): "Biosensor Technology" Marcel Dekker, 23 (1990)

K. Odashima（合著者）：“生物传感器技术”Marcel Dekker，23 (1990)

Y. UMEZAWA, M. KATAOKA, W. TAKAMI, E. KIMURA, T. KOIKE AND H. NADA: "Potentiometric adenosine triphosphate polyanion sensor using a lipophilic macrocyclic polyamine liquid membrane" Anal. Chem.60. 2392-2396 (1988)

Y. UMEZAWA、M. KATAOKA、W. TAKAMI、E. KIMURA、T. KOIKE 和 H. NADA：“使用亲脂性大环多胺液膜的电位三磷酸腺苷聚阴离子传感器” Anal。