Deciphering molecular genetic mechanisms underlying chromatin interactions

破译染色质相互作用的分子遗传机制

• 批准号: DE220101210
• 负责人: Dr Hamid Alinejad Rokny
• 金额: $ 32.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220101210
• 关键词: Deciphering; molecular; genetic; mechanisms; underlying

This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromatin pairs; ii) Comperehensive maps of regulatory interactomes in 61 tissues & cells, which will provide a roadmap for interpreting & prioritising noncoding variants. This should provide significant benefit to Australia's capacity for cutting-edge genomics research through fundamental understanding of gene regulation mechanism.

该项目旨在通过将新型机器学习工具与基因组和表观基因组数据集的强大整合通过强大的整合，在61个组织和细胞中生成高置信度图。了解基因组中的哪些关键要素对于微调基因表达至关重要，对于理解生物学途径至关重要。预期的结果包括i）稳健识别真正的染色质对的新工具； ii）61个组织和细胞中调节相互作用体的组合图，这将为解释和确定非编码变体提供路线图。 这应该通过对基因调节机制的基本理解来为澳大利亚的尖端基因组学研究能力带来重大好处。