Development of non-invasive temperature measurement system for continuous monitoring of deep brain temperatures

开发连续监测深部脑温度的无创温度测量系统

• 批准号: 13650460
• 负责人: SUGIURA Toshifumi
• 金额: $ 2.24万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650460/
• 关键词: microwave radiometry; hypothermia; newborn baby; brain temperature; non-invasive measurement; hypoxia; weighting function; brain; 低体温療法; 脳; 脳内温度分布; マイクロ波ラジオメトリ; 脳内電磁界解析; 信頼区間; 脳機能障害; ラジオメトリ; 脳内電磁解析; 脳障害後遺症; ラジオメータ; 熱雑音; 較正実験

It has been shown that cooling the brain of newborn baby after hypoxia-ischemia can reduce damage and improve functional outcome. Clinical trials are, however, currently hindered by the difficulty in measuring brain temperature non-invasively. Microwave radiometry has been proposed and developed as a non-invasive technique for brain temperature measurement at Shizuoka University. The radiometer system detects the very weak spontaneous electromagnetic radiation from inside the brain by a waveguide antenna placed on the head surface and amplifies them with five receivers operating at center frequencies of 1.2, 1.65, 2.3, 3.0 and 3.6 GHz. The system also includes two lock-in amplifiers, control circuit, reference noise source, and the temperature retrieval algorithm.Among the five receivers, 2.3, 3.0 and 3.6 GHz receivers have been added to the 1.2 and 1.65 GHz receivers that were previously made, and a control program for the whole system has been developed. In addition to those, several … More circuits such as buffer circuits, constant voltage/current circuits, supply circuits, etc. were manufactured. In order to operate stably not in a shielded room but in a normal room, several countermeasures for reducing background noises and thermal fluctuation have been made to the system. After such improvements, the system became stable in a normal room, and a calibration experiment could be done using a waveguide antenna. Temperature resolutions for the five receivers were 0.183, 0.273, 0.148, 0.108, 0.118 ℃. New radiometric weighting functions were also obtained from baby's MRI data. Confidence interval at the brain center was estimated by the temperature retrieval simulation method, which also developed for the evaluation of the system, using the obtained resolutions and a temperature shape function in a baby's head. The interval thus obtained was about 0.3 ℃. This result was satisfactory in comparison with the target value of 1 ℃. Manufacturing the temperature distribution phantom of a baby's head and the further countermeasures for stabilization of the system for temperature measurement experiment are now underway. Less

已经表明，在缺氧 - 异常后冷却新生婴儿的大脑可以减少损害并改善功能结果。然而，目前，临床试验因无创测量大脑温度的困难而阻碍。 Shimaoka大学已提出并开发了微波辐射指定，并作为一种用于脑温度测量的非侵入性技术。辐射计系统通过放置在头表面上的波导天线从大脑内部检测到非常弱的赞助商高度电磁辐射，并在中心频率下以1.2、1.65、2.3、3.0和3.6 GHz进行放大。该系统还包括两个锁定放大器，控制电路，参考噪声源以及五个接收器的温度检索算法，2.3、3.0和3.6 GHz接收器已添加到先前制作的1.2和1.65 GHz接收器中，并且已经开发了整个系统的控制程序。除此之外，还制造了几个……更多的电路，例如缓冲电路，恒定电压/电流电路，电源电路等。为了使稳定不在屏蔽的房间中，而是在普通房间中，对系统进行了几种减少背景噪声和热波动的对策。改进后，该系统在普通房间内变得稳定，五个接收器的校准实验温度分辨率为0.183、0.273、0.148、0.108、0.118℃。还从BABY的MRI数据中获得了新的辐射加权功能。通过温度检索模拟方法估算了大脑中心的置信区间，该方法还使用所获得的分辨率和婴儿头部的温度形状功能开发了用于系统的评估。间隔该结果约为0.3℃。与目标值1℃相比，该结果令人满意。现在正在进行制造婴儿头部的温度分布幻影，并正在进行进一步的与温度测量实验系统稳定的对策。较少的

项目成果

A study of the influence of tissue conductivity for microwave radiometric weighting functions in non-invasive measurement of baby's brain temperature

无创婴儿脑温测量中组织电导率对微波辐射加权函数影响的研究

• 发表时间: 2002
• 期刊: Proceedings of 2002 IEEE Asia-Pacific Microwave Conference
• 作者: T.Sugiura;Y Kouno;A.Hashizume;H.Hirata;Y.Okita;M.Kimura;J.W.Hand;S.Mizushina;Toshifumi Sugiura;Toshifumi Sugiura
• 通讯作者: Toshifumi Sugiura

Development of a five-band microwave radiometer system for non-invasive measurement of deep brain temperature in new-born babies

开发五波段微波辐射计系统，用于无创测量新生婴儿深部脑温度

• 发表时间: 2002
• 期刊: Proceedings of 2002 IEEE Asia-Pacific Microwave Conference
• 作者: T.Sugiura;Y Kouno;A.Hashizume;H.Hirata;Y.Okita;M.Kimura;J.W.Hand;S.Mizushina;Toshifumi Sugiura
• 通讯作者: Toshifumi Sugiura

七種隆光, 北村 光, 平田 寿 他: "サンプルアンドホールド回路を用いた基準雑音源制御法"静岡大学電子工学研究所研究報告. 36巻. 123-127 (2003)

Takamitsu Nanagusa、Hikaru Kitamura、Hisashi Hirata 等：“使用采样保持电路的参考噪声源控制方法”静冈大学电子研究所研究报告，第 36 卷，123-127 (2003)。

K.Ohashi, K.Maruyama, H.Hirata, et al.: "One dimensional radiometiric weighting functions in 3D baby head models"Proceedings of JICAST'02. 211-214 (2002)

K.Ohashi、K.Maruyama、H.Hirata 等人：“3D 婴儿头部模型中的一维放射测量权重函数”JICAST02 论文集。

T.Sugiura, H.Hirata, K.Ohashi, et al.: "A study of the influence of tissue conductivity for microwave radiometric weighting functions in non-invasive measurement of baby's brain temperature"Proceedings of 2002 Asia-Pacific Microwave Conference. 1091-1094

T.Sugiura、H.Hirata、K.Ohashi 等人：“组织电导率对婴儿脑温度无创测量中微波辐射加权函数影响的研究”2002 年亚太微波会议论文集。