Deployment and establishment adult living donor liver transplantation-Development of the immunosuppression treatment based on gene analysis treatment based on a gene analysis

成人活体肝移植的部署和建立-基于基因分析的免疫抑制治疗的开发基于基因分析的治疗

• 批准号: 13307038
• 负责人: TANAKA Koichi
• 金额: $ 23.46万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13307038/
• 关键词: Liver transplantation; Living donor; Immunity seppression treatment; Memory T cell; Effecter T cell; Cytochrome P450; P glycoprotein; 成人生体肝移植; C型肝炎; 遺伝子解析; 拒絶反応; 薬剤代謝遺伝子; 免疫寛容

It aged 1998, the adult liver transplant from a living donor was introduced completely, and it came for the deployment and establishment as much as possible.In this research period, exact analysis of the vascular construction in the computer picture analysis based on 3DCT was carried out, and the selection and operation technique of the high liver graft of safety based on this were established.As a result, the adult liver transplant from a living donor progressed quickly in this institution, brought about expansion of an adaptation case, the increase in the number of cases, and the improvement in results, and contributed to society greatly.However, the results do not have few examples of early death by postoperative complications by the high risk group in which various internal-organs obstacles are accepted from before an operation, either.The greatest point for this improvement is a measure against infection accompanying each optimal immunity control treatment and immunity insufficiency to a patient.Then, P glycoprotein analysis was performed with Cyp3a4,5 which participates in the medicine metabolism of small intestine membrane about the metabolism of immunosuppressant tecrolimus, and the difference in each patient's immunity control medicine metabolism was clarified.Before and after operation CD45 isoform expression profiling It carried out, using sequential analysis [of a naive using T-lymph cell / memory T lymph cell, and an effecter T-lymph cell / memory T-lymph cell] in peripheral blood lymphocyte.Consequently, we have classified recipients into five groups and established the tailor-maid immunity control treatment to determine the amount of optimal dosage and the medication method of immunosappressants according to five groups.By this research, the adult liver transplant from a living donor can be developed more safely.

完全引入了1998年的1998年，是完全引入了来自活体供体的成年肝移植，它是为了尽可能多地进行部署和建立。在本研究期内，对计算机图片分析中的血管结构进行了精确分析，基于3DCT进行了计算机图片分析中的血管结构，以及基于这一结果的高肝脏的选择，基于这一范围的高肝脏的选择。适应案例的增加，案件数量的增加以及结果的改善以及对社会的贡献。但是，既然高风险群体没有术后并发症的早期死亡的例子，而高风险群体的术后并发症早期并不是在操作前接受各种内部障碍的障碍。用CYP3A4,5进行糖蛋白分析，该分析参与小肠膜的药物代谢，涉及免疫抑制剂tecrolimus的代谢，并在每个患者的免疫控制医学代谢中的差异在使用CD45同型的核心表达仪式上进行了序列分析，并在使用cd45 cill cinter cylime-nimply-nemply-nemply-nemphimist [ cell, and an effecter T-lymph cell / memory T-​​lymph cell] in peripheral blood lymphocyte.Consequently, we have classified recipients into five groups and established the tailor-maid immunity control treatment to determine the amount of optimal dosage and the medication method of immunosappressants according to five groups.By this research, the adult liver transplant from a living donor can be developed more safely.

项目成果

Koji Umeshita et al.: "Operative morbidity of living liver donors in Japan"The lancet. (2003)

Koji Umeshita 等人：“日本活体肝脏捐献者的手术发病率”柳叶刀。

S.Fukatsu: "Population phamacokinetics of tacrolimus in adult recipients recieving living-donor liver transplantation"EUR J CLIN PHARMACOL. 57. 479-484 (2001)

S.Fukatsu：“接受活体肝移植的成年受者中他克莫司的群体药代动力学”EUR J CLIN PHARMACOL。

Hironori Haga: "Periportal Edema And Necrosis As Diagnostic Histologic Features Of Early Humoral Rejection In A B O - Incompatible Liver Transplantation"Liver Transplantation. 9・12. 1-12 (2003)

Hironori Haga：“A B O 中早期体液排斥的门静脉周围水肿和坏死的诊断组织学特征 - 不相容性肝移植”9・12（2003 年）。

Hiroshi Hisatsune: "Endoscopic Management Of Billary Strictures Aafter Duct-To-Duct Biliary Reconstruction In Right-Lobe Living-Donor Liver Transplantation"Transplantation. 76・5. 810-815 (2003)

Hiroshi Hisatsune：“右叶活体肝移植中胆道狭窄的内镜治疗”76・5（2003）。

Kasahara M et al.: "Monosegmental living donor liver transplantation for infantile hepatic hemangioendothelioma"J pediatr Surg.. 38,7. 1108-1111 (2003)

Kasahara M 等人：“单节段活体肝移植治疗婴儿肝血管内皮瘤”J pediatr Surg. 38,7。