Formation and Retention of Novel Framework of Metal Complexes through multi-elemental sites

通过多元素位点形成和保留金属络合物新型框架

基本信息

批准号：
12650678
负责人：
NOMURA Ryoki
金额：
$ 2.3万
依托单位：
Osaka Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

It is found that some novel complex assembly can be synthesized by an introduction of hydrogen bonding sites such as OH groups on the outer sphere of transition metal dithiocarbarnate complexes. For example, we prepared novel dithiocarbarnate complexes of transition metals having OH groups at the positions leading to C2 symmetry and some Ni and Cu complexes can form novel complex assembly with micro-channel structure. These micro-channel structures should lead to developing a new receptor. On the other hand, Zn analogues did not form such complex assemblies but formed dimmer with bridging dithiocarbamate ligands. Omega OH groups of the Zn complexes surrounding (Zn-S) 2 core maintained C2 symmetry against the core. Consequently, an approach of some guest molecules may stimulate OH groups on the outer sphere to change the conformation around the central metals. This finding perhaps leads to new biosensors.Next we investigated the scope and limitations of such type of complex assembly for developing new bio-sensing devices. For example, preparation of some zinc complexes with N-protected oligo-peptide chains as ligands was investigated. Further, spectral investigations on the intermolecular and/or inter-ligand interactions of those zinc complexes were attempted. Thus, it is found that these oligo-peptide chains can form some inter ligand interactions although they were locked to the central metals. Additionally, it can be said an approach of some marker molecules to the ligand should affect the conformational change around the central metals. Such conformational changes were considered to actuate the signals generated by the approach of the marker.

发现可以通过引入氢键位点（例如OH基团）在过渡金属二硫代碳纤维复合物上的OH基团等引入氢键位点来合成一些新型的复合物。例如，我们制备了新型的二硫代毛肉体复合物的过渡金属，其在导致C2对称的位置的OH基团和一些Ni和Cu复合物可以形成具有微通道结构的新型复合组装。这些微通道结构应导致开发新的受体。另一方面，Zn类似物并未形成这样的复杂组件，而是通过桥接二硫代氨基盐配体形成变暗器。围绕（Zn-S）2核心的Zn复合物的Omega OH组保持了C2对称性的对称性。因此，某些来宾分子的方法可能会刺激外球体上的OH基团改变中央金属周围的构象。这一发现也许会导致新的生物传感器。我们研究了这种类型的复杂组装的范围和局限性，用于开发新的生物敏感设备。例如，研究了一些用N保护的寡肽链制备一些锌配合物，作为配体。此外，尝试了对这些锌配合物的分子间和/或配体相互作用的光谱研究。因此，发现这些寡肽链可以锁定在中央金属上，但它们可以形成一些配体相互作用。此外，可以说某些标记分子对配体的方法应影响中央金属周围的构象变化。认为这种构象变化是通过标记方法产生的信号。