Efficient Mixing or Liquid/Liquid-Extraction in Zigzag-Shaped Microchannel

之字形微通道中的高效混合或液/液萃取

基本信息

批准号：
12640578
负责人：
KIM Haeng-boo
金额：
$ 2.24万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12640578/
关键词：
microchannel shape effect mixing liquid liquid extraction microspectrosco flow profile

项目摘要

The Flow characteristics in a microchannel, operated by pressure-driven flow, are described by a low Reynolds-number flow : laminar flow. In laminar flow, the flow line runs parallel with the cannel-wall, so that the inertial effects on molecular motions and the turbulent mixing of solution do not occur. Owing to such flow characteristics, even when two solutions are introduced separately into a microchannel chip, the two folutions in the single channel can flow witout any mutual mixing. On the other hand, molecular diffusion along the channel-width direction take place, thus, solute molecules dissolved in one solution phase can cdistributed to the other phase : diffusional mixing, while the efficiency is insufficient. It is supposed that the flow characteristics might be influenced by the shape of the channel. In this study, therfore, shape effects of microchannel on a mixing of two miscible solutions and liquid/liquid extraction of two immiscible solutions were explored by usin spatially-resolved microspectroscopy. Polymer-substrate chips having a flat-side-walled channel (symmetrical and unsymmetrical zigzag side walled) were fabricated. In the unsymmetrical zigzag-side walled channel, the interface was sinusoidal reflecting on the shape, while it was flat in flat-or symmetrical-side-walled channel. Since the interface shape affects on contact time of the two solutions, the unsymmetrical zigzag-side walled channel syowed the most efficient mixing or extraction efficiency. In the symmetrical zigzag channel. the efficiency become worse than in flat-shape channel because of retention flow. These results were also supported fro, flow analysis by mathematical calculation.

由压力驱动流操作的微通道中的流动特性通过低雷诺数流来描述：层流。在层流中，流线与通道壁平行，因此不会发生分子运动的惯性效应和溶液的湍流混合。由于这种流动特性，即使将两种溶液分别引入微通道芯片中，单个通道中的两种溶液也可以流动而不会相互混合。另一方面，分子沿通道宽度方向扩散，因此溶解在一个溶液相中的溶质分子可以分布到另一相中：扩散混合，但效率不够。据推测，流动特性可能受到通道形状的影响。因此，在本研究中，利用空间分辨显微光谱技术探讨了微通道的形状对两种互溶溶液的混合和两种不互溶溶液的液/液萃取的影响。制造了具有平坦侧壁通道（对称和不对称之字形侧壁）的聚合物基底芯片。在非对称锯齿形侧壁通道中，界面在形状上呈正弦曲线，而在平坦或对称侧壁通道中，界面是平坦的。由于界面形状影响两种溶液的接触时间，因此不对称的锯齿形侧壁通道表现出最有效的混合或萃取效率。在对称之字形通道中。由于滞留流，效率比扁平通道差。这些结果也得到了数学计算流量分析的支持。