Develop of High Performance Stents

高性能支架的开发

• 批准号: 12358017
• 负责人: MATSUDA Takehisa
• 金额: $ 19.1万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12358017/
• 关键词: stent; covered stent; endothelial cell; エキシマ・レーザ; 光加工

This project aimed to develop high performance stents which enable to reduce the hyperplasia in diseased coronary arteries. Two new approaches were designed and tested : One approach is covered stent in which microporous segmented polyuretheve thin film is wrapped on the stent to prepare a covered stent on which high photoreactive coating enabled sustained release of an incorporated drug. The in vivo study verified that heparin release eventually reduced the intimal hyperpleasia. The other approach is to delivery endothelial progenitor cells (EPC) autologously harvested from the circulating peripheral blood. EPC "paving " from the EPC-seeded stents resulted in full endothelialization at denuded arteries, resulting in rapid wound healing. Thus, the project was completed with high outcome.

该项目旨在开发高性能支架，以减少患病冠状动脉的增生。设计并测试了两种新方法：一种方法是覆盖支架，其中将微孔分段聚氨酯薄膜包裹在支架上以制备覆盖支架，其上的高光反应性涂层能够实现掺入药物的持续释放。体内研究证实，肝素释放最终减少了内膜增生。另一种方法是输送从循环外周血中自体收获的内皮祖细胞（EPC）。 EPC 植入支架的 EPC“铺路”导致裸露动脉完全内皮化，从而导致伤口快速愈合。至此，该项目圆满完成。

项目成果

Takehisa Matsuda and Manabu Mizutani: "Molecular Design of Photocurable Liquid Biodegradable Copolymers.2.Synthesis of Coumarin-Derivatized Oligo (methacrylate) s and Photocuring."Macromolecules. 33(3). 791-794 (2000)

Takehisa Matsuda 和 Manabu Mizutani：“光固化液体可生物降解共聚物的分子设计。2.香豆素衍生寡聚（甲基丙烯酸酯）的合成和光固化。”大分子。

Nishi S, Nakayama Y, Ishibashi-Ueda H, Matsuda T.: "Occulusion of Experimental Aneurysms with Heparin-Loaded, Microporous Stent Grafts"Reprinted from Nerurosurgery. Vol.53,Number6. 1397-1405 (2003)

Nishi S、Nakayama Y、Ishibashi-Ueda H、Matsuda T.：“用装载肝素的微孔支架移植物进行实验性动脉瘤闭塞”，转载自《神经外科》。

H.Okino, Y.Nakayama, M.Tanaka, T.Matsuda: "In situ hydrogelation of photocurable gelatin and drug release"J Biomed Master Res. 59. 233-245 (2002)

H.Okino、Y.Nakayama、M.Tanaka、T.Matsuda：“光固化明胶的原位水凝胶化和药物释放”J Biomed Master Res。

Takehisa Matsuda,Manabu Mizutani et al.: "Molecular Design of Photocurable Liquid Biodegradable Copolymers,1.Synthesis and Photocuring Characteristics."Macromolecules. 33(3). 795-800 (2000)

Takehisa Matsuda、Manabu Mizutani 等人：“光固化液体可生物降解共聚物的分子设计，1.合成和光固化特性。”高分子。

M.Gohda, T.Magoshi, S.Kato, T.Noguchi, S.Yasuda, H.Nonogi, T.Matsuda: "Terminally Alkylated Heparin. 2. Potent Antiproliferative Agent for Vascular Smooth Muscle Cells"Biomacromolecules. 2(4). 1178-1183 (2001)

M.Gohda、T.Magoshi、S.Kato、T.Noguchi、S.Yasuda、H.Nonogi、T.Matsuda：“末端烷基化肝素。2.血管平滑肌细胞的有效抗增殖剂”生物大分子。