Is the metastasis promoted by the radiotherapy? -Studies on cellular fibrinolysis of tumor-

放疗是否促进转移？

基本信息

批准号：
11670917
负责人：
KAJIWARA Akihiko
金额：
$ 2.18万
依托单位：
AICGI MEDICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670917/
关键词：
Cellular fibrinolysis Radiaotherapy Hyperthermia Metastasis Invation uPA tPA PAI-1 tPA

项目摘要

The cancer keeps the first of cause of death still, and people fear it. The most large cause of their fear is the metastasis of the cancer. There are still no therapy and drug which prevent the metastasis of the cancer.Whether radiotherapy and hyperthermia of topical treatment of the cancer promote the metastasis of the cancer is an important problem. It was to not consider that the metastasis was promoted by the irradiation and/or hyperthermia. However, it was to often experience. Metastasis and invasion of the cancer derived from human after the irradiation and/or hyperthermia treatment were examined in vitro and in vivo (using the tumor-transplanted nude mouse) from cellular fibrinolysis of the cancer, and these clinical indexes were studied.Cellular fibrinolysis of AOI tumor cells derived from human lung cancer and OST tumor cells derived from human osteosarcoma was increased by irradiation, and U87MG tumor cells derived from human glioblastoma was increased by hyperthermia treatment. Metastasis of AOI tumor cells and OST tumor cells transplanted nude mice was promoted by irradiation. Metastasis of U87MG transplanted nude mice was promoted by hyperthermia treatment.From the result of mRNA expression and production quantity of cellular fibrinolysis and metastasis of transplanted nude mouse, the possibility of promoting transposition, invasion and recurrence of the human tumor of the high transposable of some tumors was demonstrated by irradiation and/or hyperthermia treatment.It became clear that the expression of cellular fibrinolytic factors of the tumor cell became an index of mutasion, invasion and recurrence of the cancer after radiotherapy and hyperthermia treatment.

癌症仍然是死亡原因，人们担心它。他们担心的最大原因是癌症的转移。仍然没有预防癌症转移的疗法和药物。癌症的局部治疗的放射疗法和高温促进癌症的转移是一个重要问题。它不是考虑到转移是通过辐照和/或热疗促进的。但是，这是经常经历的。辐射和/或高温治疗后，从人类的细胞纤维蛋白解析在体外和体内（使用肿瘤移植的裸小鼠）在癌症中检查了从人类的转移和侵袭癌症，并研究了这些临床指数的细胞纤维蛋白分解。通过热疗治疗增加了辐照和从人胶质母细胞瘤衍生的U87MG肿瘤细胞。通过辐射促进了AOI肿瘤细胞和OST肿瘤细胞移植的裸鼠的转移。通过高温治疗促进了U87mg移植的裸鼠的转移。从mRNA表达和细胞纤维蛋白解体的产生和生产量的结果以及移植裸小鼠的转移的转移的结果，促进某些tumodiation the the the the the the the tymos the tymos and/themerfiation and/theprols themers and/nyprolsivie the the the themardiation and/nifter the the术的可能性肿瘤细胞的细胞纤维蛋白水解因子成为放射疗法和高温治疗后癌症的叛变，侵袭和复发的指数。