Optical Resolution Membrane from Main-chin Chiral Polymer

主钦手性聚合物光学分离膜

基本信息

批准号：
11650906
负责人：
AOKI Toshiki
金额：
$ 2.24万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11650906/
关键词：
Main-chain Chirality Asymmmetric Polymerization Separation Membrane Optical Resolution Phenylacetylene

项目摘要

1. Synthesis of Main-chain Chiral PolymersWe found main-chain chirality was induced when various kind of acetylene having a bulky chiral substituent. The asymmetric induction was effective when the bulky substituent is close to the main-chain.2. Syntheses of Chiral Polymers that have the chirality only in the main-chainTo clarify the effect on the enantioselective permeation, we examined synthetic methods of chiral polymers having the chirality only in the main-chain. We were able to synthesize such polymers by polymerization of a hydroxyphenylacetylene with rhodium-chiral amine catalytic system. The resulting polymers had a membrane-forming ability.3. Optical Resolution by Membranes of Main-chain Chiral PolymersMembranes from the polymers obtained in 1 showed high enantioselectivity in permeation. The content of the chiral substituent was also found to be important.4. Optical Resolution by Membranes of Chiral Polymers that have the chirality only in the main-chainSince membranes from the polymers obtained in 2 showed enantioselectivity in permeation, it was confirmed that time main-chain chirality was effective for the separation. We examined the relationship between the strength of CD signal and the selectivity.5. Effect of the main-chain chirality on enantioselective permeationFrom the results of 3 and 4, The main-chain chiralities were very effective for enantioselective permeation.

1.主链手性聚合物的合成我们发现当各种乙炔具有大的手性取代基时，会诱导主链手性。当大取代基靠近主链时，不对称诱导是有效的。2．仅在主链中具有手性的手性聚合物的合成为了阐明对对映选择性渗透的影响，我们研究了仅在主链中具有手性的手性聚合物的合成方法。我们能够通过铑-手性胺催化体系聚合羟基苯乙炔来合成此类聚合物。所得聚合物具有成膜能力。3．通过主链手性聚合物的膜进行光学拆分1中获得的聚合物的膜在渗透中表现出高对映选择性。手性取代基的含量也被发现很重要。4．通过仅在主链中具有手性的手性聚合物的膜进行光学拆分由于2中获得的聚合物的膜在渗透中显示出对映选择性，因此证实了主链手性对于分离是有效的。我们考察了CD信号强度与选择性之间的关系。 5．主链手性对对映选择性渗透的影响从3和4的结果来看，主链手性对于对映选择性渗透非常有效。