The immune response as a determinant of female reproductive investment

免疫反应是女性生殖投资的决定因素

• 批准号: DP220103487
• 负责人: Prof Sarah Robertson
• 金额: $ 45.18万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-15 至 2025-03-14
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103487
• 关键词: immune; response; determinant; female; reproductive

Aims: This project will define how ‘cryptic female choice’ affects reproductive outcomes through immune recognition of embryo histocompatibility genes, to modulate maternal nutrient provision and fetal growth. Significance: The research will tackle an important knowledge gap in animal reproduction science, where poorly-understood male-female compatibility effects cause variation in breeding efficiency with major economic and environmental impact. Expected outcomes: We expect to generate new understanding of the genes, immune response elements, and vascular changes that explain compatibility effects. Benefits: The results will inform strategies to improve fertility in livestock animals, and in rare and threatened species.

目的：该项目将通过免疫识别胚胎组织相容性基因的免疫识别来定义“神秘的女性选择”如何影响生殖结果，从而调节母鸡营养的提供和胎儿的生长。 意义：这项研究将解决动物繁殖科学中的重要知识差距，在该科学中，理解的男女兼容效果不佳会导致繁殖效率的差异，并产生重大的经济和环境影响。 预期结果：我们期望对基因，免疫响应元件和血管变化产生新的理解，从而解释兼容性效果。 好处：结果将为改善牲畜动物的生育能力以及稀有和受威胁的物种的策略提供信息。