Pathological Study of Osteonecrosis in SHRs and WKYs -Associated with Structural and Mechanical Factors-

SHR 和 WKY 骨坏死的病理学研究 - 与结构和机械因素相关 -

• 批准号: 10671367
• 负责人: SHINDO Hiroyuki
• 金额: $ 2.11万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671367/
• 关键词: Spontaneously Hypertensive Rat; Wister Kyoto Rat; Osteonecrosis; Femoral Epiphysis; Structural Strength; Mechanical Stress; Spontaneously Hypertensive Rat; Wister Kyoto Rat; Hypertensive Rat; Wistar Kyoto Rat

Osteonecrosis occurred frequently in the epiphyseal nuclei of the femoral head in SHRs and in the overloaded femoral head in WKYs during the growth period.The osteonecrosis of the proxymal femoral epiphysis in growing rats resembles that in Perthes' disease. The purpose of this study was to compare the radiographic and histologic findings of osteonecrosis of the epiphyseal nucleus of the femoral head in SHRs and WKYs. Clarifying their differences could contribute not only to systematization of the relationships among the factors participating in its etiology but could also provide a clue to the pathogenesis of Perthes' disease. The SHRs were kept in ordinary cages and the WKYs in custom-made high cage from 5 weeks to almost 15 weeks after birth (various periods). The WKYs had to stand on their hind limbs to feed because the feed box and drinking aperture were place at high level. There was a relative high incidence of avascular in the epiphyseal nuclei of the femoral heads; 45.8% in SHRs and 33.3% in WKYs. The osteonecrosis in both SHRs and WKYs resulted from interruption of the feeding vessels in the Ranvier zone. In addition to the similar findings of osteonecrosis, there were, however, several differences in the pathological condition of the proxymal femur in the SHRs and WKYs. In SHRs, there were marked cartilage abnormalities in the lateral part of the femoral head, a high incidence of ossification disturbances of the proximal femurs, such as a flattened femoral head and a short neck. In WKYs, there are no such constitutional abnormalities which may induce cartilaginous disorders. The increased mechanical stress caused by standing seems to be a causative factor of osteonecrosis in WKYs. The study suggests that standing, which applies an overloads to the hip joint, is a causative factor in osteonecrosis of the femoral head in growing rats.

生长期，SHR股骨头骨骺核和WKY股骨头超载部位常发生骨坏死。生长期间大鼠股骨近端骨骺的骨坏死与Perthes病相似。本研究的目的是比较 SHR 和 WKY 股骨头骨骺核骨坏死的影像学和组织学结果。澄清它们的差异不仅有助于系统化参与其病因学的因素之间的关系，而且还可以为珀特斯病的发病机制提供线索。出生后 5 周到近 15 周（不同时期），SHR 被饲养在普通笼中，WKY 被饲养在定制的高笼中。 WKY 必须后肢站立才能进食，因为饲料箱和饮水孔位于较高的位置。股骨头骨骺核无血管发生率较高； SHR 为 45.8%，WKY 为 33.3%。 SHR 和 WKY 的骨坏死是由于 Ranvier 区的供血血管中断造成的。然而，除了骨坏死的相似表现外，SHR 和 WKY 中近端股骨的病理状况也存在一些差异。 SHR股骨头外侧软骨异常明显，股骨近端骨化障碍发生率高，如股骨头扁平、股骨头颈短等。在 WKY 中，不存在可能诱发软骨疾病的体质异常。站立引起的机械应力增加似乎是 WKY 骨坏死的致病因素。研究表明，站立会给髋关节带来超负荷，是生长大鼠股骨头坏死的一个致病因素。

项目成果

Masatsugu Suehiro: "Etiological factors in femoral head osteonecrosis in growing rats"Journal of Orthopaedic Science. 5. 52-56 (2000)

Masatsugu Suehiro：“生长大鼠股骨头坏死的病因”骨科学杂志。

Keiji Mihara et al.: "Standing is a Causative Factor in Osteonecrosis of femoral Head in Growing Rats"Journal of Pediatric othopedics. 18. 665-669 (1988)

Keiji Mihara 等人：“站立是生长大鼠股骨头坏死的一个致病因素”《儿科骨科杂志》。

Masatugu Suehiro et al.: "Etiologic factors in femoral head osteonecrosis in growing rats"Journal of Orthopedics Science. 5-1. 52-56 (2000)

Masatugu Suehiro 等人：“生长大鼠股骨头坏死的病因”《骨科科学杂志》。

Masatsugu Suehiro: "Etiologjcal factors in femoral head osteonecrosis in growing rats"Journal of Orthopaedic Science. 5. 52-56 (2000)

Masatsugu Suehiro：“生长大鼠股骨头坏死的病因”骨科学杂志。

Keiji Mihara: "Standing is a causative factor in osteonecrosis of the femoral head in growing rats"Journal of Pediatric Orthopaedics. 18. 665-669 (1998)

Keiji Mihara：“站立是生长大鼠股骨头坏死的一个致病因素”《小儿骨科杂志》。