Dendritic mechanisms underlying a sparse spatial code in the dentate gyrus (B01)

齿状回稀疏空间编码背后的树突机制（B01）

• 批准号: 528945147
• 金额: --
• 依托单位: Lehrstuhl für Physiologie I
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/528945147?language=en
• 关键词: Dendritic; mechanisms; underlying; sparse; spatial

In the dentate gyrus, a small subset of the granule cell population takes part in an engram encoding the spatial features of the environment. Formation of this neuronal code depends on the activity-dependent changes in synaptic strength after synchronous activation of excitatory inputs that generate local dendritic activity, a process that is under tight inhibitory control. Using a combination of quantitative ultrastructural, electrophysiological and computational approaches we will study the cellular and molecular mechanisms by which dendritic excitatory and inhibitory synaptic inputs control the sparsity of granule cells engaged in the encoding of contextual information.

在齿状回中，一小部分颗粒细胞种群参与编码环境空间特征的编号。该神经元代码的形成取决于在同步激活产生局部树突活性的兴奋性输入后突触强度的变化，这一过程受到严格的抑制作用。使用定量超微结构，电生理和计算方法的结合，我们将研究细胞和分子机制，通过这些机制，树突状兴奋性和抑制性突触输入控制着参与上下文信息编码的颗粒细胞的稀疏性。