Dynamic Stereocontrol

动态立体控制

基本信息

批准号：
10208104
负责人：
KATSUKI Tsutomu
金额：
$ 55.04万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

Research Project "Dynamic Stereocontrol" has been successfully carried out for three years from 1998 to 2000 and rewarded with acquisition of new concepts for dynamic stereocontrol and invention of new methodologies for stereocontrol of organic reactions, generation of active species such as radical and carbene, and chiral separation. Representative achievements of the project are i) stereocontrol of reactions of carbonyl compounds by using a conceptually new chiral bidentate Lewis acid catalyst, ii) Construction of asymmetric reaction site by dynamic control of the conformation of achiral catalyst, iii) exploration of new type of asymmetric catalyst activated by photo-irradiation, iv) enhancement of asymmetry inducing ability of chiral catalyst by synergistic influence of achiral ligand, v) exploitation of radical reaction in aqueous medium, vi) stereocontrol of carbocation species and introduction of new methodology for construction of cyclic compounds, vii) sequential generation of … More carbon radicals and carbanions : dynamic stereocontrol in the reaction sequence, viii) construction of chiral stationary phases (CSPs) for thin layer chromatography (TLC), ix) development of molecular machine, a light-powered chiral molecular motor.In the present reasearch, the achievements obtained in the project were collected and evaluated by the research members including many distinguished chemists in our country. Furthermore, the results of the project were thouroughly discussed through the opened symposium. Based on the analysis of the results by these discussions and evaluation, the achievements were recognized to have greatly contributed to advancement of organic synthesis and chiral separation, especially to development of stereocontrol and molecular recognition.From the analysis, the necessity of continuing promotion of dynamic stereocontrol which will lay a foundation for ecologically acceptable, atom-efficient and high-yielding synthetic chemistry and for production of completely optically pure materials was also recognized.Report of the present research will be published as the research report entitled "Reseach on Dynamic Stereocontrol." Less

从1998年到2000年，研究项目“动态立体控制”已成功进行了三年，并获得了动态立体控制的新概念的奖励，并发明了有机反应的新方法的发明，生成活性物种（例如激进物种），例如自由基和碳源等活性物种，以及chiral的分离。该项目的代表性成就是i）通过使用概念上的新手性双齿刘易斯酸催化剂的符号化合物反应的定型反应，ii）通过动态控制Achiral催化剂的构象来构建不对称反应位点，III，III）通过探索新类型的非对称催化性催化剂，IIV的增强功能，IV），IV）通过附加配体的协同影响，V）在水性培养基中的根本反应，vi）carbosion物种的立体控制以及引入循环化合物构建的新方法，vii的新方法，vii）的序列产生……更多的碳雷克西和碳纤维序列（动态conereconeconters interection in vii of Racterecone）（VII In Repertuction，VII），VII Intressection（VII）的反应序列（VII），vii contrestience，VII I Rativersection，VII，对于薄层色谱（TLC），IX）分子机的开发是一种轻驱动的手性分子电机。在当前的开发中，该项目中获得的成就是由研究成员收集和评估的，其中包括我们国家的许多杰出化学家。此外，该项目的结果通过开放的研讨会进行了讨论。基于这些讨论和评估对结果的分析，确认成就有助于进步有机合成和手性分离，尤其是对立体控制和分子识别的发展，从分析到必要的动态定型，这将促进动态定型以及在生态上可接受的材料，并构成材料的基础，并在材料上构成了基础，并构成了构成纯正的纯正纯合成纯合成的纯合成纯合成，并构成了良好效率的构成纯种，既可以构成又有良好的属性，又是高雅的YELDYEILDENTY Quants north posity superty superty superty profents prof。公认的。本研究的报告将以题为“有关动态立体控制的研究”的研究报告发表。较少的