Dynamic Stereocontrol

动态立体控制

基本信息

批准号：
10208104
负责人：
KATSUKI Tsutomu
金额：
$ 55.04万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

Research Project "Dynamic Stereocontrol" has been successfully carried out for three years from 1998 to 2000 and rewarded with acquisition of new concepts for dynamic stereocontrol and invention of new methodologies for stereocontrol of organic reactions, generation of active species such as radical and carbene, and chiral separation. Representative achievements of the project are i) stereocontrol of reactions of carbonyl compounds by using a conceptually new chiral bidentate Lewis acid catalyst, ii) Construction of asymmetric reaction site by dynamic control of the conformation of achiral catalyst, iii) exploration of new type of asymmetric catalyst activated by photo-irradiation, iv) enhancement of asymmetry inducing ability of chiral catalyst by synergistic influence of achiral ligand, v) exploitation of radical reaction in aqueous medium, vi) stereocontrol of carbocation species and introduction of new methodology for construction of cyclic compounds, vii) sequential generation of … More carbon radicals and carbanions : dynamic stereocontrol in the reaction sequence, viii) construction of chiral stationary phases (CSPs) for thin layer chromatography (TLC), ix) development of molecular machine, a light-powered chiral molecular motor.In the present reasearch, the achievements obtained in the project were collected and evaluated by the research members including many distinguished chemists in our country. Furthermore, the results of the project were thouroughly discussed through the opened symposium. Based on the analysis of the results by these discussions and evaluation, the achievements were recognized to have greatly contributed to advancement of organic synthesis and chiral separation, especially to development of stereocontrol and molecular recognition.From the analysis, the necessity of continuing promotion of dynamic stereocontrol which will lay a foundation for ecologically acceptable, atom-efficient and high-yielding synthetic chemistry and for production of completely optically pure materials was also recognized.Report of the present research will be published as the research report entitled "Reseach on Dynamic Stereocontrol." Less

“动态立体控制”研究项目从1998年到2000年已成功开展了三年，获得了动态立体控制的新概念，发明了有机反应立体控制、自由基和卡宾等活性物种的生成以及有机反应立体控制的新方法。该项目的代表性成果是i）使用概念上新的手性二齿路易斯酸催化剂立体控制羰基化合物的反应，ii）通过构象的动态控制构建不对称反应位点。非手性催化剂的研究，iii) 光辐照活化新型不对称催化剂的探索，iv) 通过非手性配体的协同影响增强手性催化剂的不对称诱导能力，v) 水介质中自由基反应的开发，vi) 立体调控碳正离子种类和引入构建环状化合物的新方法，vii) 碳自由基和碳负离子的连续生成：反应序列中的动态立体控制，viii) 手性固定的构建薄层色谱（TLC）的相（CSP），ix）分子机器的开发，一种光动力手性分子马达。在目前的研究中，该项目所取得的成果被包括许多杰出化学家在内的研究成员收集和评估此外，通过召开的研讨会对该项目的成果进行了深入的讨论和评估，认为该成果对有机合成和手性分离的进步做出了巨大贡献。到分析认为，有必要继续推广动态立体控制，这将为生态可接受、原子效率和高产率的合成化学以及完全光学纯材料的生产奠定基础。报告目前的研究成果将作为题为“动态立体控制研究”的研究报告发表。