Dynamic Stereocontrol
动态立体控制
基本信息
- 批准号:10208104
- 负责人:
- 金额:$ 55.04万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas (B)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Research Project "Dynamic Stereocontrol" has been successfully carried out for three years from 1998 to 2000 and rewarded with acquisition of new concepts for dynamic stereocontrol and invention of new methodologies for stereocontrol of organic reactions, generation of active species such as radical and carbene, and chiral separation. Representative achievements of the project are i) stereocontrol of reactions of carbonyl compounds by using a conceptually new chiral bidentate Lewis acid catalyst, ii) Construction of asymmetric reaction site by dynamic control of the conformation of achiral catalyst, iii) exploration of new type of asymmetric catalyst activated by photo-irradiation, iv) enhancement of asymmetry inducing ability of chiral catalyst by synergistic influence of achiral ligand, v) exploitation of radical reaction in aqueous medium, vi) stereocontrol of carbocation species and introduction of new methodology for construction of cyclic compounds, vii) sequential generation of … More carbon radicals and carbanions : dynamic stereocontrol in the reaction sequence, viii) construction of chiral stationary phases (CSPs) for thin layer chromatography (TLC), ix) development of molecular machine, a light-powered chiral molecular motor.In the present reasearch, the achievements obtained in the project were collected and evaluated by the research members including many distinguished chemists in our country. Furthermore, the results of the project were thouroughly discussed through the opened symposium. Based on the analysis of the results by these discussions and evaluation, the achievements were recognized to have greatly contributed to advancement of organic synthesis and chiral separation, especially to development of stereocontrol and molecular recognition.From the analysis, the necessity of continuing promotion of dynamic stereocontrol which will lay a foundation for ecologically acceptable, atom-efficient and high-yielding synthetic chemistry and for production of completely optically pure materials was also recognized.Report of the present research will be published as the research report entitled "Reseach on Dynamic Stereocontrol." Less
从1998年到2000年,研究项目“动态立体控制”已成功进行了三年,并获得了动态立体控制的新概念的奖励,以及用于有机反应的立体控制的新方法,产生活性物种的产生,例如自由基和碳源和碳源和chiral分离。该项目的代表性成就是i)通过使用概念上的新手性双齿刘易斯酸催化剂的符号化合物反应的定型反应,ii)通过动态控制Achiral催化剂的构象来构建不对称反应位点,III,III)通过探索新类型的非对称催化性催化剂,IIV的增强功能,IV),IV)通过附加配体的协同影响,V)在水性培养基中的根本反应,vi)carbosion物种的立体控制以及引入循环化合物构建的新方法,vii的新方法,vii)的序列产生……更多的碳雷克西和碳纤维序列(动态conereconeconters interection in vii of Racterecone)(VII In Repertuction,VII),VII Intressection(VII)的反应序列(VII),vii contrestience,VII I Rativersection,VII,对于薄层色谱(TLC),IX)分子机的开发是一种轻驱动的手性分子电机。在当前的开发中,该项目中获得的成就是由研究成员收集和评估的,其中包括我们国家的许多杰出化学家。此外,该项目的结果通过开放的研讨会进行了讨论。基于这些讨论和评估对结果的分析,确认成就有助于进步有机合成和手性分离,尤其是对立体控制和分子识别的发展,从分析到必要的动态定型,这将促进动态定型以及在生态上可接受的材料,并构成材料的基础,并在材料上构成了基础,并构成了构成纯正的纯正纯合成纯合成的纯合成纯合成,并构成了良好效率的构成纯种,既可以构成又有良好的属性,又是高雅的YELDYEILDENTY Quants north posity superty superty superty profents prof。公认的。本研究的报告将以题为“有关动态立体控制的研究”的研究报告发表。较少的
项目成果
期刊论文数量(53)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
M.Kyoda, T.Yokoyama, H.Maekawa, T.Ohno, I.Nishiguchi: "Regioselective C-Acylation of Vinylphophorus Compounds through Electroreduction or Mg-promoted Reduction"Synlett. 10. 1535-1538 (2001)
M.Kyoda、T.Yokoyama、H.Maekawa、T.Ohno、I.Nishiguchi:“通过电还原或镁促进的还原对乙烯基磷化合物进行区域选择性 C-酰化”Synlett。
- DOI:
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- 影响因子:0
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- 通讯作者:
Y. Kita: "Selective and Facile Electroreductive Synthesis ofDihydro- and Tetrahydropyridine Dicarboxylic Acids Derivatives"Tetrahedron Letters. 40・49. 8587-8590 (1999)
Y. Kita:“二氢和四氢吡啶二羧酸衍生物的选择性和简易电还原合成”四面体快报 8587-8590 (1999)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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Tsutomu Katsuki: "Transition Metals for Organic Synthesis,Vol.2" Wiley-VCH, 261-271 (1998)
Tsutomu Katsuki:“有机合成的过渡金属,Vol.2”Wiley-VCH,261-271 (1998)
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Takateru Kubota: "Tris (cyclohexylcarbamate) s of Cellulose and Amylose as Potential Chiral Stationary Phases for High-Performance Liquid Chromatography and Thin-Layer Chromatography"Journal of American Chemical Society. 122・17. 4056-4059 (2000)
Takateru Kubota:“纤维素和直链淀粉的三(环己基氨基甲酸酯)作为高效液相色谱和薄层色谱的潜在手性固定相”美国化学会杂志 122・17(2000 年)。
- DOI:
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- 影响因子:0
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Keishi Miura: "Dynamic Control of Ligand Conformation : Asymmetric Epoxidation Using Achiral(Salen)manganese(III)Complex"Synlett. 1999・6. 783-785 (1999)
Keishi Miura:“配体构象的动态控制:使用非手性(Salen)锰(III)络合物的不对称环氧化”Synlett 1999・6(1999)。
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- 影响因子:0
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KATSUKI Tsutomu其他文献
KATSUKI Tsutomu的其他文献
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{{ truncateString('KATSUKI Tsutomu', 18)}}的其他基金
Development of environment-conscious synthetic reactions : construction of reaction coordinate-response catalyst
环境意识合成反应的发展:反应配位响应催化剂的构建
- 批准号:
18002011 - 财政年份:2006
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for Specially Promoted Research
Stereocontrol utilizing intermolecular interaction
利用分子间相互作用的立体控制
- 批准号:
10208214 - 财政年份:1998
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas (B)
Exploitation of Practical Method for Asymmetric Functionalization of Alkenes
烯烃不对称官能化实用方法的开发
- 批准号:
09554048 - 财政年份:1997
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mechanistic Study on Asymmetric Oxidations with Metallosalen Complexes as Catalysts and Exploitation of New Metallosalen Complexes
金属Salen配合物催化剂不对称氧化机理研究及新型金属Salen配合物的开发
- 批准号:
09440220 - 财政年份:1997
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of the effecient synthetic methods of some pharmeceuticals by using the generalized asymmetric epoxidation
利用广义不对称环氧化开发一些药物的有效合成方法
- 批准号:
06558093 - 财政年份:1994
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of Asymmetric Acylation Reaction by Using Chiral Leaving Group and Its Application to the Synthesis of Useful Materials
手性离去基团不对称酰化反应的进展及其在有用材料合成中的应用
- 批准号:
05680508 - 财政年份:1993
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Study on Stereocontrol in Sigmatropic Rearrangement
Sigmatropic重排立体控制研究
- 批准号:
01540455 - 财政年份:1989
- 资助金额:
$ 55.04万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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