Console renewal 400 MHz NMR spectrometer with automatic sample changer

控制台更新 400 MHz NMR 波谱仪，带自动进样器

• 批准号: 528513700
• 金额: --
• 依托单位: Ruprecht-Karls-Universität Heidelberg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/528513700?language=en
• 关键词: Console; renewal; 400; MHz; NMR

We apply the renewal of a 400 MHz NMR spectrometer using the existing superconducting magnet. The entire electronics ("console") are to be renewed, as well as the automatic sample changer. These components are outdated and prone to failure. Service from the manufacturer for these components is no longer assured ("End of Service" was in 2018 and 2016, respectively). Furthermore, the existing device can only be operated with outdated software that has not been maintained or renewed by the manufacturer since 2015. Therefore, the console and sample changer are to be replaced with new components so that the continued operation of the spectrometer is assured in the coming years.Some of the existing components can continue to be used with the new console, provided that they are compatible with the new instrument. In addition to the superconducting magnet, this concerns the shim system as well as the NMR probes and the cooling devices for measurements at variable temperature. The existing instrument is used for NMR measurements by many research groups at the Inorganic Chemistry Institute and is used to capacity. The typical application is 1D and 2D measurements of diamagnetic compounds of NMR nuclei with high to medium sensitivity such as 1H, 2H, 13C, 19F, 31P, 11B, 119Sn, 7Li. In addition, variable temperature measurements (typical range -90°C to +120°C) are often performed. In addition, measurements of paramagnetic metal complexes are of great importance. Here, a magnetic field strength of 9.4 T (i.e. 400 MHz 1H frequency) represents a good compromise between measurement sensitivity, pulse excitation width, relaxation behavior and signal dispersion. The instrument is embedded in the NMR infrastructure of the two molecular chemistry institutes, the Inorganic and the Organic Chemistry Institute of Heidelberg University (ACI and OCI, respectively). The majority of the samples at the requested instrument come from research groups at the ACI, which are all located in close proximity to the instrument. This allows measurements of very sensitive samples as well as kinetic measurements shortly after reaction start. Measurements that require a much higher sensitivity can be made on the instruments with cryo probes available at ACI and OCI. Working groups of other institutes of Heidelberg University, which need NMR measurements less frequently (e.g. from the Institute of Physical Chemistry or Biochemistry), will also be provided with the requested equipment.

我们使用现有的超导磁铁应用400 MHz NMR光谱仪的续订。整个电子设备（“控制台”）以及自动样品更换器将被更新。这些组件已过时，容易失败。不再假设制造商的这些组件的服务（分别是2018年和2016年的“服务”）。此外，现有的设备只能使用过时的软件操作，该软件自2015年以来一直没有由制造商维护或更新。因此，可以用新组件替换控制台和样品更换器，以便在未来几年中假设频谱表的持续运行。如果现有组件的一些可以继续与新的控制器一起使用，则可以使用新的控制器，这是新的仪器。除了超导磁铁外，这还涉及垫片系统以及NMR问题以及在可变温度下进行测量的冷却设备。现有的仪器用于无机化学研究所的许多研究小组进行NMR测量，并用于容量。典型的应用是NMR核的Dimagnetic化合物的1D和2D测量，具有高度至中等灵敏度，例如1H，2H，13C，19F，19F，31P，11B，11B，119SN，7LI。另外，经常进行可变的温度测量（典型范围-90°C至 +120°C）。此外，顺磁金属络合物的测量非常重要。在这里，磁场强度为9.4 T（即400 MHz 1H频率）表示测量灵敏度，脉冲兴奋宽度，松弛行为和信号分散之间的良好折衷。该仪器嵌入了两个分子化学机构的NMR基础设施中，分别是海德堡大学（ACI和OCI）的无机和有机化学研究所。所请求的仪器中的大多数样品来自ACI的研究小组，ACI都靠近该工具。这允许测量反应开始后不久的非常灵敏的样品以及动力学测量。可以在ACI和OCI上提供的冷冻探针的仪器上对需要更高灵敏度的测量值进行。海德堡大学其他研究所的工作组也将与请求的设备一起提供NMR测量的频率（例如，来自物理化学或生物化学研究所）。