Research for the perinatal adaptation of fetus and newborn ; relation to apoptosis and growth factor

胎儿和新生儿围产期适应研究；

基本信息

批准号：
08671895
负责人：
HIRAMATSU Yuji
金额：
$ 1.41万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671895/
关键词：
fetus newborn perinatal period epidermal growth factor polyamine heme metabolism diabetes mellitus placenta ポリアミン DFMO 胎児発育 EGF Apoptosis 糖代謝

项目摘要

Fetus and newborn show the many physiological and metabolic changes to adapt the dramatic environmental changes around the delivery. We investigated the hormones, growth factors and substances related to these changes.EGF increased fetal weight by controlling the amino acid transport in placenta. Retinol, insulin and insulin like growth factor also increased amino acid transport. EGF promoted the functional and morphological development of neonatal rat intestine and this change was inhibited by DL-α-difluoromethyl ornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC).Inhibition of polyamine synthesis by DFMO also induced intrauterine growth restriction. The depression of ODC activity in the placenta is the major factor of IUGR induced by DEMO administration, and polyatnines play important roles to carry pregnancy.We investigated heme metabolism in placenta. Transcription levels of the non-specific δ-aminolevulinate synthase and heme oxygenase-1 in placenta at the terminal stage of pregnancy were increased markedly and these enzymes were exclusively expressed in the trophoblast. Both enzymes were influenced by acute fetal hypoxia and suggest that placental heme metabolism is influenced by the oxygen supply.We established a sireptozotocin (STZ)-treated pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. This model closely is useful for basic study of the pathophysiology of pregnancy with diabetes.These data suggest that many hormones, growth factors and substances such as EGF, polyamine, insulin, retinoids which related to cell growth play some important roll during the perinatal period.

胎儿和新生儿表明，与变化有关的荷尔蒙，生长因子和物质的急剧变化。酸转运。EGF促进了新生儿E的功能和形态的发展，而这种变化被DL-α-二氟甲基鸟氨酸（DFMO）抑制，这是一种不可逆的抑制剂ornithine decareyine decareymine decration给药和多氨酸在胎盘中发挥着重要的作用。胎盘中的血红素代谢氧气供应。我们建立了糖尿病和症状和症状的念珠菌素（STZ）孕育大鼠模型，并与糖尿病的病理生理相关。在围产期期间，与细胞生长有关的因素和物质，例如EGF，多胺，胰岛素，类视视视网TINOITS。