Basic and Clinical study of the reconstructed organ after esophagectomy

食管癌切除术后器官重建的基础与临床研究

基本信息

批准号：
08671446
负责人：
TANGOKU Akira
金额：
$ 1.41万
依托单位：
Yamaguchi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

Pathophysiology of the reconstructed organ was examined after esophagectomy, laryngectomy and gastrectomy. Motor function of the gastric tube was examined with manometry and peristalsis was recorded. Scintigraphy showed no remarkable changes in emptying of the gastric tube after surgery. Twenty hour pH monitoring proved acid secretion in the gastric tube even after total vagotomy. Plasma gastrin release pattern was almost same as controls. Three patients with gastric tube ulcer was recognized. We developed a new portable bilirubin detecting device and duodenogastroesophageal reflux was studied. Symptomatic gastroesophageal patients showed remarkable bile reflux. Bile reflux was proved in the gastric tube after esophagectomy. Blood flow was compared between esophagectomy with and without thoracic sympatectomy by postoperative tonometry. Thoracic sympatectomy from 5 th to 10th increased blood flow of the gastric tube. Proximal gastrectomy and jejunal U-pouch interposition was done for early cardiac cancer. Pathophysiology of this procedure was studied. Gastroesophageal reflux was examined by pH monitoring and bile sensor and no remarkable reflux was recorded. Absorption was studied with plasma acetoamynophen levels and by portal blood flow monitoring with ultrasonic Doppler method.Plasma acetoamynophen increased early period but recovered to normal pattern in chronic period. Portal blood flow pattern of the U- pouch patients after meal is like controls. Gastric emptying of the U-pouch patients was resemble to normal volunteers even after total vagotomy.

在食管切除术，喉切除术和胃切除术后检查了重建器官的病理生理。用测量法检查了胃管的运动功能，并记录了蠕动。闪烁显像显示手术后没有显着的胃管排空变化。二十小时的pH监测即使在全部迷走术后，胃管中也证明了酸分泌。血浆胃释放模式几乎与对照组相同。识别三名胃管溃疡患者。我们开发了一种新的便携式胆红素检测装置，并研究了双胃食管反流。有症状的胃管患者表现出明显的胆囊反流。食管切除术后胃管中证明了胆汁反流。比较了术后骨骼术的食管切除术和不进行胸腔伴有胸腔切除术的血流。胸腔切除术从第5到10增加了胃管的血流。胃切除术和空肠U型隔离介入是针对早期心脏癌的。研究了该过程的病理生理学。通过pH监测和胆汁传感器检查胃食管反流，并且没有记录显着的反流。使用血浆乙酰促鼻酚水平和通过超声多普勒方法监测的门口血流进行了研究。Plasmaacetoamynophen增加了早期，但在慢性时期恢复到正常的模式。餐后u袋患者的门户血流模式就像对照。即使在整个整体迷走神经切开术后，U袋患者的胃排空也与正常的志愿者类似。