Long-term potentiation of the corticorubral synapse produced by cerebro-cerebellar communication

脑-小脑通讯产生的皮质红质突触的长期增强

• 批准号: 07680894
• 负责人: ODA Yoichi
• 金额: $ 1.47万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680894/
• 关键词: red nucleus; long-term potentiation; corticorubral synapse; interpositorubral synapse; excitatory postsynaptic potential; cat; guinea pig; シナプス可塑性; 運動制御; 小脳-赤核シナプス; 連合学習

The red nucleus (RN) is located at the key position in the cerebrocerebellar communication system in mammals. The RN in cat receives direct projection from both the interpositus nucleus of cerebellum and sensorimotor and association cortices. The former makes synapses on the soma or proximal dendrites and the latter on the peripheral dendrites of the RN.It was reported that tetanization of the corticorubral fibers produced posttetanic potentiation, which lasted a few minutes, of the excitatory postsynaptic potentials (EPSPs) mediated by the corticorubral synapses. However, a long-term potentiation (LTP) has not been found at the synapses. In the present study, we demonstrated that conjunction of the tetanic stimulation of the corticorubral fibers and interpositorubral fibers induces an LTP of the corticorubral EPSPs. The LTP likely occurs specifically at the corticorubral synapses, since there was no change in either the interpositorubral EPSPs or input resistance of the RN cells. Thus, it is suggested that the conjunctive activities of the cerebral and cerebellar outputs induce a long-lasting change in the efficacy of corticorubral transmission, which may underlie motor learning of the voluntary movement mediated by the RN.

红色核（RN）位于哺乳动物的脑脑通信系统中的关键位置。 CAT中的RN从小脑和感觉运动和缔合皮层接收直接投影。 The former makes synapses on the soma or proximal dendrites and the latter on the peripheral dendrites of the RN.It was reported that tetanization of the corticorubral fibers produced posttetanic potentiation, which lasted a few minutes, of the excitatory postsynaptic potentials (EPSPs) mediated by the corticorubral synapses.但是，在突触中尚未发现长期增强（LTP）。在本研究中，我们证明了皮质纤维纤维和骨插纤维纤维的四季刺激的结合会诱导皮质肾脏EPSP的LTP。 LTP可能专门发生在皮层突触上，因为骨插曲的EPSP或RN细胞的输入电阻都没有变化。因此，建议大脑和小脑输出的结合活性会引起皮质延伸的疗效的持久变化，这可能是RN介导的自愿运动的运动学习。

项目成果

Morita,M.: "Quantal analysis of long-term potentiation at inhibitory synapse of the goldfish Mauttrner cell" Jpn.J.Physiol. 45. S134 (1995)

Morita,M.：“金鱼 Mauttrner 细胞抑制性突触长期增强的定量分析”Jpn.J.Physiol。

Kawasaki,K.: "Inhibitory long-term potentiation underlying halituation of goldfish escape responce." Jpa.J.Physiol. (in press). (1995)

Kawasaki,K.：“金鱼逃避反应的厌食的抑制性长期增强。”

Oda,Yoichi: "Inhibitory long-term potentiation underlying long-lasting habituation of goldfish escape response" Neurosci. Res.Suppl.20. S244 (1996)

Oda，Yoichi：“金鱼逃逸反应的长期习惯化背后的抑制性长期增强”神经科学。

Kawasaki,Keisuke: "Long-lasting habituation of Mauthner cell-initiated escape response of goldfish" Neunosci. Res.Suppl.20. S244 (1996)

川崎圭介：“毛特纳细胞引发的金鱼逃逸反应的长期习惯”Neunosci。

Oda, Y.: "Inhibitory long-term patenfiation underlying long-lasting habituation of goldfish escape response." Neurosic.Res.S20. S244 (1996)

Oda, Y.：“抑制性长期专利化是金鱼逃避反应长期习惯化的基础。”