N-6 and n-3 polyunsaturated fatty acid supplement in the treatment of liver cirrhosis.

补充N-6和N-3多不饱和脂肪酸治疗肝硬化。

• 批准号: 07680037
• 负责人: OKITA Misako
• 金额: $ 1.41万
• 依托单位: Okayama Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680037/
• 关键词: liver cirrhosis; alcoholic liver injury; arachidonic acid; 6-keto prostaglandin F1alpha; leukotriene B4; dietary fat; fatty acid; アラキドン酸油; 亜鉛; 脂質過酸化; プロスタグランディンE_2; ロイコトリエンB_4; 脂肪酸栄養; n-3脂肪酸; n-6脂肪酸; リン脂質

1. The serum phospholipid contents and the fatty acid compositions in the phospholipids were analyzed in 24 cirrhotic patients, and they were compared with those of control patients with no liver disease. Serum phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidylethanolamine (PE) levels in the cirrhotic patients were significantly lower than those in the control patients. Significant decreases in the molar composition of arachidonic acid in PC, PI and PE were recognized in the serum of cirrhotic patients compared with the levels in the controls. The arachidonic acid/linoleic acid molar ratios in the serum PI and PE of cirrhotic patients were also significntly lower than those of the controls, as was the docosahexaenoic acid contents in the patients. None of the patients showed deficient dietary intake of polyunsaturated fatty acid in the cirrhotic patients. It is concluded that the metabolism of linoleic acid to arachidonic acid and alpha-linolenic acid to DNA may be de … More layd in the cirrhotic liver, and supplement of arachidonic acid and DHA may be useful for the nutritional treatment of liver cirrhotic patients.2. Ethanol-treated rats were fed with two kinds of dietary fat, lard or arachidonic acid-rich oil, for 14days. Ethanol was administered by gavage at a single daily dose of 3g/kg body weight. Significantly lower levels of arachidonic acid and arachidonic/linoleic acid ratio and higher levels oleic acid in liver phospholipid were observed in the ethanol-treated fed with lard compared to sucrose administered control rats. The arachidonic acid-rich oil-diet induced a marked increase of arachidonic acid and subsequent significant decrease of linoleic acid both in the liver and plasma phospholipid in ethanol-treated rats. Oleic acid in the plasma and liver triglyceride in ethanol-treated rats were also markedly decreased by feeding arachidonic acid-rich oil. The level of 6-keto prostaglandin F1alpha was elevated markedly in the ethanol-treated rats fed with arachidonic acid rich oil. Liver leukotriene B4 level was not increased by feeding arachidonic acid-rich oil. These results may suggest some beneficial effects of arachidonic acid supplement to the patients with alcoholic liver injury or liver cirrhosis. Less

1。在24例肝硬化患者中分析了磷脂中的血清磷脂含量和脂肪酸成分，并将其与无肝病对照患者的患者进行了比较。肝硬化患者的血清磷脂酰胆碱（PC），磷脂酰肌醇（PI）和磷脂酰乙醇胺（PE）水平明显低于对照患者的肝硬化患者。与对照的水平相比，在肝硬化患者的血清中，PC，PI和PE中蛛网膜酸的摩尔组成显着降低。肝硬化患者的血清PI和PE中的花生四烯酸/亚油酸摩尔比也明显低于对照组的摩尔酸摩尔比，而患者的二十二碳六烯酸含量也是如此。肝硬化患者中，没有一个患者表现出多不饱和脂肪酸的饮食不足。得出的结论是，亚油酸对蛛网膜酸和α-烯醇酸对DNA的代谢可能是在肝硬化肝脏中更多的，而蛛网膜酸和DHA的补充可能可用于肝肝硬化患者的营养治疗。乙醇处理的大鼠用两种饮食脂肪，猪油或富含花生四烯酸的油喂养14天。乙醇通过每日3g/kg体重的每日剂量以饲料施用。与蔗糖施用的对照大鼠相比，在乙醇治疗的喂养的乙醇处理的喂食中，观察到肝磷脂中的花生四烯酸和蛛网膜酸/亚油酸比率和较高的油酸水平。芳基酸富油含量诱导的蛛网膜酸显着增加，随后在肝脏处理的大鼠中肝脏和血浆磷脂中的亚油酸显着降低。通过喂养富含花生四烯酸的油，还显着降低了乙醇处理大鼠血浆和肝甘油三酸酯中的油酸。在用富含花生四烯酸的乙醇处理的大鼠中，6-酮前列腺素F1alpha的水平显着升高。通过喂养富含花生四烯酸的油，肝白细胞B4水平并未升高。这些结果可能表明蛛网膜酸补充剂对酒精性肝损伤或肝硬化患者的一些有益作用。较少的

项目成果

渡辺明治: "肝硬変例におけるアラキドン酸欠乏と肝発癌" Pharma Medica. 15・3. 168-180 (1997)

Meiji Watanabe：“肝硬化病例中的花生四烯酸缺乏和肝癌发生”Pharma Medica 15・3（1997）。