Nutritional Therapy of HCV-infected patients using vitamin E and C and eicosapentaenoic acid.

使用维生素 E、C 和二十碳五烯酸对 HCV 感染患者进行营养治疗。

• 批准号: 16500516
• 负责人: OKITA Misako
• 金额: $ 2.43万
• 依托单位: Okayama Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500516/
• 关键词: eicosapentaenoic acid; vitamin E; lymphocyte; fatty acid composition of RBC; arachidonic acid; interferon; ribavirin; hepatitis C patients; リンパ球数; 8-OHdG; インターフェロンα-2b

Antiviral therapy using interferon (IFN) α-2b and ribavirin is an important component in the treatment of hepatitis C virus infected patients. However, hemolytic anemia and cytopenia are well known side effects of IFN α-2b and ribavirin therapy. We, therefore, examined the effects of anti-oxidative vitamin and EPA supplementation on the prevention of side effects in the patients treated with IFN α-2b and ribavirin.1. Vitamin E and C supplementation in the treatment of chronic hepatitis C patientsPatients were randomly allocated to receive daily 500mg of vitamin E and 750mg of vitamin C (vitamin group, n=14) or no supplement (non-vitamin group, n=16) in addition to IFN α-2b and ribavirin therapy. The fatty acid composition of mononuclear cell phospholipids was analyzed before and at 2, 4 and 8 weeks after treatment.After vitamin supplementation, plasma and RBC α-tocopherol and plasma ascorbic acid levels increased in the vitamin group. Serum ALT levels decreased significantly after 2 we … More eks of treatment in both groups. At the start of treatment, a lower level of EPA and a higher level of the molar ratio of arachidonic acid to EPA in mononuclear cells were observed in the patients compared with healthy volunteers, and a significant correlation between the molar ratio and serum ALT level was found. The EPA level of mononuclear cells was maintained in the vitamin group during treatment, whereas a significant decrease was observed in the non-vitamin group at 4 and 8 weeks after treatment. From these results, usefulness of vitamin E, C and EPA supplementation was expected in the treatment of chronic hepatitis C.2. EPA supplementation in the treatment of chronic hepatitis C patientsEPA ethyl ester capsules were administered to patients receiving the combination therapy of IFN α-2b and ribavirin. EPA (1,800mg/day) was supplemented in combination with vitamin E (300mg/day) and C (600mg/day) to 5 chronic hepatitis C patients (EPA group). Five patients were administered vitamin E and C but not EPA (control group).EPA in erythrocyte membrane rose to 3 fold the basal level in the EPA group, while it decreased significantly in the control group after 24 weeks of therapy. Lymphocyte counts in the EPA group increased after 4 weeks of therapy and maintained the basal level throughout therapy, whereas the counts decreased significantly in controls. The serum ALT was improved significantly in the EPA group. Changes in lymphocyte counts following 24 weeks of therapy correlated with the EPA level in erythrocyte. These results may suggest the beneficial effect of EPA in the treatment of chronic hepatitis C patients. Less

使用干扰素（IFN）α-2B和利巴韦林是治疗丙型肝炎病毒感染患者的重要组成部分。然而，溶血性贫血和细胞质是IFNα-2B和利巴韦林治疗的众所周知的副作用。因此，我们研究了抗氧化维生素和EPA补充对预防IFNα-2B和Ribavirin.1患者的副作用的影响。1。在慢性丙型肝炎患者治疗中的维生素E和C补充剂随机分配每天接受500mg维生素E和750mg的维生素C（维生素组，N = 14）或无补充（非VITAMIN组，n = 16，n = 16），除IFN IFN IFN IFN IFN IFN IFN IFN IFN IFN IFN IFN IFN IFNIFNIDα-2b和ibraviririn治疗外。治疗前2、4和8周分析了单核细胞磷脂的脂肪酸组成。补充维生素后，维生素组的血浆和RBCα-生育酚和血浆抗坏血酸水平增加。两组中，血清ALT水平显着降低。在治疗开始时，与健康的志愿者相比，在患者中观察到较低水平的EPA和较高的单核细胞中蛛网酸与EPA的摩尔比，发现摩尔比与血清ALT水平之间的显着相关性。在治疗过程中，在维生素组中保持了单核细胞的EPA水平，而在治疗后4和8周，非维生素组的非维生素组显着降低。从这些结果中，预期补充维生素E，C和EPA的有用性在治疗慢性肝炎C.2。在接受IFNα-2B和利巴韦林联合疗法的患者中，对慢性丙型肝炎患者的慢性肝炎治疗中的EPA补充。 EPA（1,800mg/天）与维生素E（300mg/天）和C（600mg/天）结合补充，至5例慢性丙型肝炎患者（EPA组）。五名患者接受了维生素E和C，但不服用EPA（对照组）。红细胞膜中的EPA上升到EPA组的基本水平3倍，而在治疗24周后，对照组的基本水平显着降低。在治疗4周后，EPA组中的淋巴细胞计数增加，并在整个治疗过程中保持基本水平，而对照组的计数显着降低。 EPA组的血清ALT显着改善。治疗后24周后，淋巴细胞计数的变化与红细胞的EPA水平相关。这些结果可能表明EPA在治疗慢性丙型肝炎患者中的有益作用。较少的

项目成果

Vitamin E supplementation increases polyunsaturated fatty acids of RBC membrane in HCV infected patients.

补充维生素 E 会增加 HCV 感染患者红细胞膜的多不饱和脂肪酸。

• 发表时间: 2004
• 期刊: Nutrition 20-4
• 作者: Yasuko Ota;Takayo Sasagawa;Kazuhiko Suzuki;Kayoko Tomioka;Ayako Nagai;Gohichi Niiyama;Miwa Kawanaka;Gotaro Yamada;Misako Okita
• 通讯作者: Misako Okita

Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon α-2b and ribavirin.

补充维生素 E 和 C 可防止慢性丙型肝炎患者在干扰素 α-2b 和利巴韦林联合治疗期间单核细胞中二十碳五烯酸的减少。

• 发表时间: 2006
• 期刊: Nutrition 22・2
• 作者: Hatsue Moritaka;Fumiko Nakazawa;森高初惠他;Yasuko Murakami
• 通讯作者: Yasuko Murakami

Chronic hepatic disease and dietary instruction.

慢性肝病与饮食指导。

• 发表时间: 2004
• 期刊: Hepatology Research 30S
• 作者: Kayoko Tomioka;Naoko Kakibuchi;Yasuko Murakami;Takayo Kawakami;Kouichi Takaguchi;Keiji Kita;Misako Okita;Yasuko Ota;Misako Okita
• 通讯作者: Misako Okita

C型慢性肝炎のPEG-IFNα-2b/ribavirin併用療法における亜鉛投与のALT値改善効果(投与開始8週目までの検討)

PEG-IFNα-2b/利巴韦林联合疗法治疗慢性丙型肝炎时，锌给药对改善 ALT 水平的影响（开始给药后长达 8 周的研究）

• 发表时间: 2006
• 期刊: 肝臓 (印刷中)
• 作者: Yasuko Murakami;Ayako Nagai;Takayo Kawakami;Keisuke Hino;Akira Kitase;Yuh-ichi Hara;Michiari Okuda;Kiwamu Okita;Misako Okita;村上 泰子
• 通讯作者: 村上 泰子

Effects of eicosapentaenoic acid supplementation in the treatment of chronic hepatitis C patients.

补充二十碳五烯酸对慢性丙型肝炎患者治疗的影响。

• 发表时间: 2005
• 期刊: J Nutr Sci Vitaminol. 51
• 作者: Tomioka;K.
• 通讯作者: K.