Expression of natriuretic peptides in heart failure

心力衰竭中利尿钠肽的表达

• 批准号: 07670795
• 负责人: YOSHIMURA Michihiro
• 金额: $ 1.47万
• 依托单位: Kumamoto University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670795/
• 关键词: A-type (atrial) natriuretic peptide; B-type (brain) natriuretic peptide; Heart failure; B型(脳性)カリウム利尿ペプチド; 心房性(A型)ナトリウム利尿ペプチド; 脳性(B型)ナトリウム利尿ペプチド

A-type (atrial) natriuretic peptide and B-type (brain) natriuretic peptide (BNP) are novel cardiac peptides. The plasma levels of ANP and BNP are increased as heart failure advances. This study was performed to investigate the precise secretion patterns of ANP and BNP and the pathophysiological roles of ANP and BNP in heart failure. In the present study, we found that ANP is secreted mainly from the atria moreover also from the ventricles as heart failure advances. On the other hand, BNP is secreted mainly from the ventricles regardless of the severity of heart failure, suggesting the important dual natriuretic peptide system in heart failure. In the infarct ventricles, BNP especially increased from the adjoining site to the infarct area. ANP and BNP not only improve left ventricular function, but also may inhibit the ventricular remodeling after myocardial infarction. Thus, ANP and BNP have cardioprotective effect in heart failure. Further more, we found that BNP is secreted also in patients with unstable angina. The finding is important in the pathophysiology of ischemic heat disease. We examined the effects of the BNP infusion on systemic hemodynamic parameters and coronary circulation, too. These results suggest that ANP and BNP are involved in the pathophysiology of many cardiac disorders.

A型（心房）利钠肽和B型（脑）利钠肽（BNP）是新型心脏肽。随着心力衰竭的进展，ANP 和 BNP 的血浆水平升高。本研究旨在探讨 ANP 和 BNP 的精确分泌模式以及 ANP 和 BNP 在心力衰竭中的病理生理作用。在本研究中，我们发现 ANP 主要从心房分泌，而且随着心力衰竭的进展，也从心室分泌。另一方面，无论心力衰竭的严重程度如何，BNP 主要从心室分泌，这表明双利尿钠肽系统在心力衰竭中很重要。在梗塞心室中，BNP从邻近部位到梗塞区域尤其增加。 ANP和BNP不仅可以改善左心室功能，还可能抑制心肌梗死后的心室重构。因此，ANP和BNP对心力衰竭具有心脏保护作用。此外，我们发现不稳定型心绞痛患者也会分泌 BNP。这一发现对于缺血性热病的病理生理学具有重要意义。我们还研究了 BNP 输注对全身血流动力学参数和冠状动脉循环的影响。这些结果表明 ANP 和 BNP 参与许多心脏疾病的病理生理学。

项目成果

K.Okumura,et.al.: "Brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans" J Am Coll Cardiol. 25. 342-348 (1995)

K.Okumura 等人：“脑（B 型）钠尿肽对人类冠状动脉直径和冠状动脉血流动力学变量的影响”J Am Coll Cardiol。

K.Kikuta, et.al.: "Increased plasma levels of B-type Natriuretic peptide in patients with unstable agnina pectoris" Am Heart J. 132. 101-107 (1996)

K.Kikuta 等人：“不稳定型胸痛患者 B 型钠尿肽血浆水平升高”Am Heart J. 132. 101-107 (1996)

Kato H., Yasue H., Yoshimura M., Tanaka H., Miyao Y., Okumura K., Ogawa H., Nakao K.: "Suppression of Hyperventilation-induced attacks With Infusion of B-type (Brain) Natriuretic Peptide in Patients With Variant Angina." Am Heart J.128. 1098-104 (1995)

Kato H.、Yasue H.、Yoshimura M.、Tanaka H.、Miyao Y.、Okumura K.、Okawa H.、Nakao K.：“通过输注 B 型（脑）钠尿肽抑制过度换气引起的发作

吉村 道博 他: "ANP、BNP" 現代医療. 57. 2265-2271 (1995)

Michihiro Yoshimura 等：“ANP，BNP”现代医学 57. 2265-2271 (1995)。

H.Kato,et.al.: "Suppression of hyperventilation-induced attacks with infusion of B-type (brain) natriuretic peptides in patients with variant angina" Am Heart J. 128. 1098-1104 (1995)

H.Kato 等人：“变异型心绞痛患者输注 B 型（脑）钠尿肽可抑制过度换气引起的发作”Am Heart J. 128. 1098-1104 (1995)