Survival Analysis and Prognosis for Children with Severe Motor and Intellectual Disabilities Syndrome (SMIDS)

严重运动和智力障碍综合征 (SMIDS) 儿童的生存分析和预后

• 批准号: 07670458
• 负责人: YOKOYAMA Eise
• 金额: $ 1.54万
• 依托单位: NIHON UNIVERSITY,SCHOOL OF MEDICINE,
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670458/
• 关键词: SMIDS; Survival Analysis; Prognosis; 重症心身障害児; 出生時体重

Purpose : In order to investigate factors affecting the prognosis for Children (patients) with Severe Motor and Intellectual Disabilities Synfrome"SMIDS", we calculated mortality and survival rate.Methods : We obtained a 14 year (from 1979 to 1993) survival rate for such patients cared at home from their health checkup data and fatal case reports by visiting nurse program in Tokyo.The number of the patients documented was 690 (alive 523, dead 167).The survival rate was calculated on these documented patients according to Kaplan-Meier's method and Cox's proportional hazard model was applied to the findings in order to analyze the factors affecting prognosis. The patient's grade of severity (Ooshima's Classification, Jittai Chousa Hyou Bunrui), posture, capabilities of locomotion, convulsion, way of feeding, weight at birth and etc.were selected from the SMID checklist items (by Nakamura) and survey data as variables for analysis.Results and Conclusion : The average death rate was 2.31% per year. The survival rate for the group with tube feeding was 43.8% (during 14 years)From the findings of proportional hazard model, it was suggested that prognosis depend significantly on the patient's way of feeding (tube feeding), which therefore deserves more attention and improvement.

目的：为了调查影响患有严重运动和智力残疾儿童预后的因素，我们计算了死亡率和生存率。 167）。根据Kaplan-Meier的方法对这些记录的患者进行了计算，Cox的比例危害模型被应用于发现，以分析影响预后的因素。患者的严重程度（Ooshima的分类，Jittai Chousa Hyou Bunrui），姿势，移动能力，抽搐能力，抽搐，喂养方式，出生时的体重以及从SMID清单项目（Nakamura）中选择的。从比例危害模型的发现中，该组喂食的组的存活率为43.8％（在14年内），建议预后显着取决于患者的喂养方式（管喂养），因此值得更多的关注和改善。