Polyunsaturated fatty acids in plasma and mononuclear cell phospholipids of patients with atopic eczema.

特应性湿疹患者血浆和单核细胞磷脂中的多不饱和脂肪酸。

• 批准号: 07670432
• 负责人: NASU Yutaka
• 金额: $ 1.41万
• 依托单位: NAGANO COLLEGE OF NURSING
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670432/
• 关键词: Atopic-Eczema; Polyunsaturated Fatty Acid; Phospholipid; Gamma-linolenic Acid; Linoleic Acid; Arachidonic Acid; リノレン酸; 慢性炎症性疾患

Recent studies of polyunsaturated fatty acids (PUFA) in plasma and blood cell components of patients with atopic diseases have indicated disordered fat metabolism as linoleic acid (18 : 2n-6) tends to be increased while the more unsaturated fatty acids, such as gamma-linolenic acid (18 : 3n-6) and arachidonic acid (20 : 4n-6) are present in decreased amounts. In atopic eczema patients, the delta-6-desaturase function should be impaired, then the amount of linoleic acid should be increased, on the other hand those of the linoleic acid metabolites should be decreased. And so when the direct metabolite of linoleic acid, gamma-linolenic acid, is adminostered for the patients, then the symptoms of this disease should be disappeared.No significant differences were seen between control and patients before treatment. By the treatment of EFA,dihomogamma-linolenic acid (20 : 4n-6) was significantly decreased and behenic acid (22 : 1n-9? ) significantly increased.Linoleic acid (18 : 2n-6) of patients looked like to be increased compared with control group and decreased after treatment, though not significantly. And more unsaturated fatty acids, such as homogamma-Iinolenic acid and arachidonic acid looked decreased after treatment.

最新的对特应疾病患者血浆和血细胞成分的多不饱和脂肪酸（PUFA）的研究表明，脂肪代谢无序代谢（18：2N-6）倾向于增加，而较不饱和的脂肪酸却增加了，而gamma-linolenicaci酸（18：3n-6）和araChIci-arach-arach-arachicsic（20：4N），而含量更不饱和脂肪酸。在特应性湿疹患者中，应损害Delta-6-二节至饱和酶功能，然后应增加亚油酸的量，另一方面，应降低亚油酸代谢产物的含量。因此，当对患者施加亚油酸的直接代谢产物，γ-亚麻酸时，该疾病的症状应消失。在治疗前，对照组和患者之间没有显着差异。通过对EFA的治疗，二莫加 - 甲酚酸（20：4N-6）显着降低，而贝尼酸（22：1n-9？）显着增加。林酸（18：2n-6）的患者看起来像是与对照组相比，看起来像是增加的，尽管治疗后不显着减少，但并未显着减少。治疗后，更多的不饱和脂肪酸，例如同型二苯二酚和花生四烯酸。

项目成果

D. C. E. Nordstrom, VEAHonkanen, Y. Nasu, E. Antila, C. Friman, Y. T. Konttinen: "Alpha-linolenic acid in the treatment of rheumatoid arthritis, A double-blind, placebo-controlled and randomized study : flaxseed vs, safflower seed" Rheumatol Int. 14. 231-

D. C. E. Nordstrom、VEAHonkanen、Y. Nasu、E. Antila、C. Friman、Y. T. Konttinen：“α-亚麻酸治疗类风湿性关节炎，一项双盲、安慰剂对照和随机研究：亚麻籽与红花籽”

D.C.E.Nordstrom, VEA Honkanen, Y.Nasu, E.Antila, C.Friman, Y.T.Konttinen: "Alpha-linolenic acid in the treatment of rheumatoid arthritis. Adouble-blind,placebo-controlled and randomized study : flaxseed v.s.safflower seed." Rheumatol Int. 14. 231-234 (199

D.C.E.Nordstrom、VEA Honkanen、Y.Nasu、E.Antila、C.Friman、Y.T.Konttinen：“α-亚麻酸治疗类风湿性关节炎。一项双盲、安慰剂对照和随机研究：亚麻籽与红花籽。”

D.C.E.Nordstrom, V.E.A.Honkanen, Y.Nasu, E.Antila, C.Friman, Y.T.Konttinen: "Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study : Flaxseed vs.Safflower seed." Rheumatol Int. 14. 231-234 (

D.C.E.Nordstrom、V.E.A.Honkanen、Y.Nasu、E.Antila、C.Friman、Y.T.Konttinen：“α-亚麻酸治疗类风湿性关节炎。一项双盲、安慰剂对照和随机研究：亚麻籽与红花籽