"Development of ultrasonic diagnosis system for early-stage arteriosclerosis using impulsive actuator"

“利用脉冲执行器开发早期动脉硬化超声诊断系统”

基本信息

批准号：
07555124
负责人：
CHUBACHI Noriyoshi
金额：
$ 6.27万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

In this research, we have developed a new method to measure local pulse wave velocity, which is an index of the hardness in the range of several millimeters on the aortic wall. In the standard method, the pulse wave velocity (PWV) is obtained from the difference in arrival time of pressure waves propagating from the carotid artery to the femoral artery. In this method, the measurable points are limited to those where the aorta exists near the skin surface and the distance between such points is considerable long, i. e., several hundred millimeters. It is important for early diagnosis, however, to measure the local hardness of the surface of the arterial wall. To increase the spatial resolution, it is necessary to measure vibrations due to pulse waves with frequency components up to about 50 Hz.Therefore, we have developed a new system to noninvasively measure small vibration signals on the heart wall or the aortic wall from the surface of the skin based on the ultrasonic Doppler effect. By this system, small vibrations with amplitudes of 10-100mum on the motion due to heart beat with the large amplitude of 10 mm are successfully detected in the frequency range up to 1 kHz continuously for more than ten beat periods from the chest.To improve the spatial resolution in the local velocity measurement of vibration propagating on the arterial wall, this research also developed a new method to actuate impulsive wave with higher frequency components until 1 kHz from the backbone and transcutaneously measure the transit delay time of the impulsive wave propagating two proximate points on the aortic wall. The method offers potential for research in acoustical diagnosis of arteriosclerosis.

在这项研究中，我们开发了一种测量局部脉搏波速度的新方法，这是主动脉壁上几毫米范围内硬度的指数。在标准方法中，脉冲波速度（PWV）是从从颈动脉传播到股动脉的压力波的到达时间差异获得的。在这种方法中，可测量的点仅限于主动脉在皮肤表面附近并且这种点之间的距离相当长的地方。例如，几百毫米。然而，对于早期诊断而言，重要的是测量动脉壁表面的局部硬度。为了增加空间分辨率，有必要由于频率成分的脉搏波测量振动，最高约为50 Hz。因此，我们开发了一种新系统，以基于超声多普勒的超声多普勒效应，从皮肤表面上从心脏壁或心脏壁上的无创振动信号进行了无创测量的小振动信号。通过该系统，由于心跳引起的运动幅度为10-100mum的幅度幅度为10毫米，在频率范围内成功地检测到了10毫米的大幅度，从胸部连续进行了十个以上的节奏，从胸部连续进行十次以上的节奏，以改善频率在局部速度上的空间分辨率，以在频率上进行频率，以使这一频率播放的频率逐渐播放，这是在振动中播放的频率，这是振动效果的新方法。直到1 kHz从骨架上进行1 kHz，并经常测量脉冲波在主动脉壁上传播两个接近点的延迟时间。该方法为动脉硬化的声学诊断提供了研究。