Development of Biological Ultrasonic Micro-Specroscopy System

生物超声显微光谱系统的研制

基本信息

批准号：
63880033
负责人：
CHUBACHI Noriyoshi
金额：
$ 4.86万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

A biological ultrasonic micro-spectroscopy (Bio-UMS) system has been developed as a new research tool to characterize biological soft and hard tissues on a microscopic scale in the VHF and UHF ranges.A method has been developed for measuring the bulk acoustic properties such as velocity, attenuation, and density in reflection and transmission modes with the biological soft tissue specimen sandwiched between the parallel surfaces of fused quartz buffer rods having ZnO piezoelectric film transducers on their opposite ends. The method is an acoustic transmission line comparison method wherein the reference medium is distilled water. Techniques of precise mechanical alignment for parallelism of the two rod surfaces, movement to adjust the gap distance, and signal processing are involved in order to obtain high measurement accuracy. Results of measurements with bovine tissues of liver, heart muscle, and fat have been presented.A reflection-type acoustic microscope system for biological soft … More tissue characterization has been developed. This system operates in both amplitude and phase modes, and can measure acoustic properties, viz., velocity and attenuation, of tissues in two-dimensional color imaging, as well as at arbitrary points in an imaging area. A demonstration for dog cardiac infarcted tissues prepared from a formalin-fixed, paraffin-embedded sample has been made. Spatial hanges of acoustic properties in tissues due to pathological degeneration were quantitatively determined. A revised model for the quantitative characterization has been also proposed wherein the effects of acoustic multiple reflection and viscosity of the sample have been taken into account.Acoustic microscopy has been discussed to investigate viscoelastic properties of biological hard tissues, taking dental materials. The quantitative applications of an line-focus-beam (LFB) acoustic microscope, as well as the imaging applications of a point-focus-beam (PFB) acoustic microscope, have satisfactorily demonstrated the possibilities. In particular, the LFB acoustic microscope can be expected to play an important role as a powerful tool to solve basic and practical problems in all kinds of dental materials, including dental hard tissues of enamel and dentine, and dental porcelains and composites for repairing human teeth. Less

已经开发了一种生物性超稳态微光谱（Bio-UMS）系统，是一种新的研究工具，可以在VHF和UHF范围内在微观尺度上表征生物学柔软和硬时，A开发了用于测量散布性和变化范围诸如速度，衰减和密度的柔软程度的范围的散布式的AA方法。熔融石英缓冲杆的表面，其相对的两端具有ZnO压电膜传感器。该方法是一种声传输线比较方法，其中参考介质是蒸馏水。为了获得较高的测量精度，涉及两个杆表面和信号处理的运动，调节间隙距离和信号处理的运动，调节间隙距离和信号处理的精确机械比对技术。已经提出了用肝脏，心肌和脂肪的牛组织测量结果。用于生物柔软的反射型声学显微镜系统……已经开发了更多的组织表征。该系统以放大器和相模式运行，可以测量二维颜色成像中组织的声学特性，即速度和衰减，以及成像区域中的任意点。已经制作了由福尔马林固定的石蜡装满样品制备的狗心脏梗塞组织的演示。由于已经提出了用于定量表征的修订模型，因此已经提出了由于已经考虑了声学多重反射和样品粘度的影响，因此已经考虑了声学显微镜研究，以研究生物学硬组织的粘弹性，采用牙科材料。线对焦梁（LFB）声学显微镜的定量应用，以及点对焦梁（PFB）声学显微镜的成像应用，都令人满意地证明了可能性。特别是，LFB声学显微镜可以作为解决各种牙科材料（包括搪瓷和牙本质的牙科硬组织）以及牙齿瓷器和复合材料来修复人类牙齿的强大工具的重要作用。较少的