Factors contributing to regional clustering of gallbladder cancer in Niigata district

新泻县胆囊癌区域聚集性影响因素

• 批准号: 07457281
• 负责人: YOSHIDA Keisuke
• 金额: $ 4.35万
• 依托单位: The Nippon Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457281/
• 关键词: Gallbladder cancer; Lipids in gallbladder bile; Panacreaticobiliay maljunction; Gallbladder stone

1. Incidence of pancreaticobiliary maljunction (PBMJ) in Niigata district.Incidence of high amylase activity (>10.OOOIU/L) in gallbladder bile among cholecystectomy cases was 2.3% (7/305) and incidence of PBMJ among ERCP cases was 2.7% (63/2336). These results suggests that incidence of PBMJ in Niigata is not paticularly high comparing to other parts of Japan. Therefore, it is not likely that PBMJ plays an important role in the high incidence of galllbladder cancer in Niigata.2. Bile acids and fatty acids in gallbladder bile.Bile acid concentration in gallbladder bile decreased prominently in patients with gallbladder cancer and those with cholesterol stone in a lesser degree. Ratio of secondary to primary bile acids increased in gallbladder cancer. Disturbance of concentrating function of the gallbladder seemed to precede to cystic duct obstruction or mucosal devastation secondary to carcinoma.Fatty acid concentration was also very low in gallbladder cancer. However, individual difference in fatty acid concentration is so large that meaning of this change must be evaluated after accumulation of much more number of cases.3. Mutagenecity of gallbladder bile.Preliminary results of Ames test of gallbladder bile showed slightly lower incidence of mutagenic bile in recent cases. To confirm this tendency, it is necessary to follow longer in much more cases.

1. 新泻县胰胆管连接不良（PBMJ）发生率。胆囊切除病例中胆囊胆汁高淀粉酶活性（>10.OOOIU/L）的发生率为2.3%（7/305），ERCP病例中PBMJ的发生率为2.7% (63/2336)。这些结果表明，与日本其他地区相比，新泻县的 PBMJ 发病率并不是特别高。因此，PBMJ在新泻县胆囊癌高发中起重要作用的可能性不大。2．胆囊胆汁中的胆汁酸和脂肪酸。胆囊癌患者胆囊胆汁中的胆汁酸浓度显着下降，胆固醇结石患者的下降程度较轻。胆囊癌中次级胆汁酸与初级胆汁酸的比率增加。胆囊浓缩功能的紊乱似乎先于胆囊管阻塞或继发于癌症的粘膜破坏。胆囊癌中脂肪酸浓度也非常低。但脂肪酸浓度的个体差异较大，必须在大量病例积累后才能评估这种变化的意义。 3．胆囊胆汁的致突变性。胆囊胆汁的Ames试验初步结果显示，近期病例中致突变胆汁的发生率略低。为了证实这种趋势，有必要在更多情况下进行更长时间的跟踪。

项目成果

Tetsuya Ohtani, C.Kawai, Y.Shirai, K.Kawakami and K.Yoshida: "Intraoperative Ultrasonography Versus Cholangiography During Laparoscopic Cholecystectomy : A Prospective Comparative Study." Journal of the American College of Surgeons. vol.185, No.3. 274-282

Tetsuya Ohtani、C.Kawai、Y.Shirai、K.Kawakami 和 K.Yoshida：“腹腔镜胆囊切除术期间的术中超声检查与胆管造影：一项前瞻性比较研究。”

Hiroshi Mano, Ivan roa E., Juan Carlos Araya, T.Ohta, K.Yoshida, K.Araki, H.Kinebuchi, T.Ishizu, H.Nakadaira, K.Endoh, M.Yamamoto and H.Watanabe: "Comparison of mutagenic activity of bile between Chilean and Japanese female patients having cholelithiasis.

Hiroshi Mano、Ivan roa E.、Juan Carlos Araya、T.Ohta、K.Yoshida、K.Araki、H.Kinebuchi、T.Ishizu、H.Nakadaira、K.Endoh、M.Yamamoto 和 H.Watanabe：“比较

Hiroshi Mano: "Comparisom of mutagemic activity of bile between Chilean and Japanese female patients having chdelithiasis." Mutation Research. 371・1. 73-77 (1996)

Hiroshi Mano：“患有胆结石的智利和日本女性患者的胆汁突变活性的比较。”371・1（1996）。