The pathology of Ki-1 lymphoma

Ki-1淋巴瘤的病理学

• 批准号: 07457048
• 负责人: MORI Shigeo
• 金额: $ 3.9万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457048/
• 关键词: Malignant lymphoma; Anaplastic large cell lymphoma; chimerie gene; Translocation of chromosome; Hodgkin's disease; ホジキン病; CD30; キメラ蛋白; 染色体; 転座

Ki-1 lymphoma is a subtyper of human malignant lymphoma comprizing its 2-7%. Whlee the pathogenetic mechanism of Ki-1 lymphoma remained unknown, we noted a novel chimeRic protein p80, composed partly ALK gene on chromosome 2 and partly of nucleophosmin gene on chromosome 5, is highly expressed on 40% of Ki-1 lymphomas. IN the present study, we formed that p80 affects normal signal transduction passway on positive (swutch-on) way at a certain points causing high proliferation of host cells. Also formd the ALK gene to be highly expressed in murine brain, suggesting its normal role on nerve function.Peculiarly, with the co-operation of oversea groups, we found that p80 is expressed highly in Ki-1 lymphomas but not in Hodgkin's desease that share similar histopathology. It is our conclusion that Ki-1 lymphoma expressing p80 is a unique disease entity in phenotype as well as pathogenesis

Ki-1淋巴瘤是占其2-7％的人类恶性淋巴瘤的亚型。我们注意到，Ki-1淋巴瘤的致病机制尚不清楚，我们注意到一种新型的嵌合蛋白p80，该蛋白p80在染色体2上部分烷基基因组成，部分在5染色体基因上，在Ki-1淋巴瘤中高度表达了40％的染色体基因。在本研究中，我们形成的是，p80在一定点上影响正常信号转导通道，从而导致宿主细胞的高增殖。还形成了在鼠大脑中高度表达的碱基因，这表明其在神经功能上的正常作用。当然，在海外组的合作下，我们发现p80在Ki-1淋巴瘤中高度表达，但在霍奇金的脱后酶中没有表达相似的组织病理学。我们的结论是，表达p80的Ki-1淋巴瘤是表型中的独特疾病实体，以及发病机理

项目成果

Yee HT,Ponzoni M,Merson A,Mori S,Frizzera G,Inghirami G: "Molecular characterization of the t(2 ; 5)(p23 ; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease." Blood. 87. 1081-1088 (1996)

Yee HT、Ponzoni M、Merson A、Mori S、Frizzera G、Inghirami G：“间变性大细胞淋巴瘤 (Ki-1) 和霍奇金病中 t(2 ; 5)(p23 ; q35) 易位的分子特征。”

Fujimoto J,Shiota M,Iwahara T,Seki N,Sato H,Mori S,Yamamoto T: "Characterization cell line with chromosomal translocation t (2 ; 5)" Proc Natl Acad Sci USA. 93. 4181-4186 (1996)

Fujimoto J、Shiota M、Iwahara T、Seki N、Sato H、Mori S、Yamamoto T：“染色体易位 t (2 ; 5) 的细胞系表征”Proc Natl Acad Sci USA。

Shiota M and Mori S: "The clinicopathologic features of anaplastic large cell lymphomas expressing p80 (review)" Leukemia and Lymphoma. 23. 25-32 (1996)

Shiota M 和 Mori S：“表达 p80 的间变性大细胞淋巴瘤的临床病理特征（综述）”白血病和淋巴瘤。

Yee HT,Ponzoni M,Merson A,Goldstein M,Scarpa A,Chilosi M,Menestrina F,Pittaluga, S,Wolf-Peeters CD,Shiota M,Mori S, Frizzera G,Inghirami G: "Molecular charactirization of the t (2 ; 5) (p23 ; q35) translocation in anaplastic large cell lymphoma (Ki-1) and

Yee HT，Ponzoni M，Merson A，Goldstein M，Scarpa A，Chilosi M，Menestrina F，Pittaluga，S，Wolf-Peeters CD，Shiota M，Mori S，Frizzera G，Inghirami G：“t的分子表征（2

Shiota M,Nakamura S,Ichinohasam,K Mori S: "Anaplastic large clle lymphomas expressing the novel chimerie protein p80 NPM/ALK,a distiret clinieopallelogic entity" Blood. 85. 1954-1960 (1995)

Shiota M、Nakamura S、Ichinohasam、K Mori S：“表达新型嵌合蛋白 p80 NPM/ALK 的间变性大细胞淋巴瘤，一种令人沮丧的临床对应实体”血液。