ULTRA MICRO-MORPHOLOGICAL CHANGE OF A SMALL CALIBER

小口径的超微观形态变化

• 批准号: 06557072
• 负责人: SATOH Shinichi
• 金额: $ 2.5万
• 依托单位: KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557072/
• 关键词: smallcaliber graft; gelatin-heparin; smooth musle cell; artficial matrix; ultrafin polyester fiber

The development of a small caliber arterial graft is difficult because it need an antithrombogenicity for the patency. The gaft incubated the endtherial cell (hybrid graft) could not be developed because the endtheial cells could not exist on the surface of the graft without of fibroblasts and smooth musle cells. So we developed a small caliber gaft which have following characteristics : (1) ultafine polyester fibers were used for the structual framework, and (2) two kinds of protein were used for biodegradable matrices ; one is cross-linked gelatin-heparin complex as an artficial intima the others heated denatured albumin as an artificial matrix. And the results of the implantation was excellent and we examind the micromorphological changes of the gaft after implantation, which leads farther remold of this graft which has more ex cellent patency.

小口径动脉移植物的开发很困难，因为它需要抗血栓形成才能保持通畅。培养内皮细胞的移植物（混合移植物）无法发育，因为如果没有成纤维细胞和平滑肌细胞，内皮细胞就不能存在于移植物表面。因此我们开发了一种小口径纤维，其具有以下特点：（1）采用超细聚酯纤维作为结构框架，（2）采用两种蛋白质作为可生物降解基质；一种是交联明胶-肝素复合物作为人工内膜，另一种是加热变性白蛋白作为人工基质。植入效果良好，并观察植入后移植物的微观形态变化，使移植物进一步重塑，通畅性更加良好。

项目成果

Shinichi Satoh et al: "Development of a method to prevent degenerative changes of the vein gaft for arterial reconstruction" J.Jpn.Surg.Soc. 93. 419-428 (1991)

Shinichi Satoh 等人：“开发一种防止动脉重建中静脉退行性变化的方法”J.Jpn.Surg.Soc。

Shinichi Satoh et al: "Autologous connective tissue tube graft with good healing process" Jpn J artif Organs. 19. 1074-1077 (1990)

Shinichi Satoh 等人：“自体结缔组织管移植具有良好的愈合过程”Jpn J artif Organs。

Satoshi Niu et al: "A simple method of incorporating fabric grafts with temprary antithrombogenicity" Jpn J biomaterials. 11. 264-272 (1993)

Satoshi Niu 等人：“一种将织物移植物与临时抗血栓形成性结合的简单方法”Jpn J 生物材料。

Shinichi Satoh et al: "Clinical use of low porosity woven ultrafine polyester fiber grafts" Artif Organs. 19. 57-63 (1995)

Shinichi Satoh 等人：“低孔隙率编织超细聚酯纤维移植物的临床应用”Artif Organs。

Keiichi Kanda et al: "Development of a smalldiameter vascular prosthesis composed of highly-oriented dense collagen fibers" Jpn J artif Organs. 24. 185-189 (1995)

Keiichi Kanda 等人：“开发由高度定向致密胶原纤维组成的小直径血管假体”Jpn J artif Organs。