Synthetic Studies for Ample Supply of Biologically Active Natural Products

生物活性天然产物充足供应的合成研究

基本信息

批准号：
05303011
负责人：
IRIE Hiroshi
金额：
$ 7.17万
依托单位：
Ngasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05303011/
关键词：
Biologically active natural products Asymmetric Synthesis Organometalic Chenistry Modification of amino acid Development of chiral synthon Ample supply of useful enzymes 生理活性微量天然物合成アミノ酸修飾生物活性天然物海洋性天然物甘味成分アレニルスルホニウム Tautomycin,

项目摘要

Reacenty, many biologically active natural products, which are available to the precise investigation of the biological transmission mechanism in molecular level, have been isolated and characterized. However, it is quite dificult to obtain such kind of compounds from natural sources. For example, it is well-known that some spider toxins inhibit the exitement neuro-transmimmision in brain and are suitable tool to investigate such transmission mechanism. Since the gain of these toxins in pure forms from natural sources is impossible, their ample supplies have been required by their syntheses. Irie and his co-workers (Nagasaki University and Hokkaido University) have accomplished a new method to synthesize these toxins using the azide group in the place of amino group for the construction of the polyamine side chains in toxins. This method makes the supply of the considerably large amount of toxins possible. Tkahashi (Tokyo Institute of Technology) has developed a new method which is available to synthesize some biologically active poly-succaride chains. Fujii (Kyoto University) has synthesized some poly-peptides having an possibility to develop of new drug against AIDS.Uemura (Shizuoka Unversity) investigated the toxic substances produced by a marine shell and elucidated the structure of genuin toxin possessing the possibility to design new drug. And all the members of this project have carried out high-lebel of research works evluated all the world and published large number of the reports on international scientific journals.

近年来，许多具有生物活性的天然产物已被分离和表征，可用于分子水平上生物传播机制的精确研究。然而，从天然来源获得此类化合物相当困难。例如，众所周知，一些蜘蛛毒素会抑制大脑中的兴奋神经传递，并且是研究这种传递机制的合适工具。由于不可能从天然来源获得这些毒素的纯净形式，因此它们的合成需要充足的供应。 Irie 和他的同事（长崎大学和北海道大学）完成了一种合成这些毒素的新方法，使用叠氮基代替氨基来构建毒素中的多胺侧链。这种方法使得供应相当大量的毒素成为可能。 Tkahashi（东京工业大学）开发了一种新方法，可用于合成一些具有生物活性的多糖链。 Fujii（京都大学）合成了一些多肽，具有开发抗艾滋病新药的可能性。Uemura（静冈大学）研究了海洋贝壳产生的有毒物质，并阐明了Genuin毒素的结构，具有设计新药的可能性。该项目的所有成员都开展了受到世界各国评价的高水平研究工作，并在国际科学期刊上发表了大量报告。