Chemical Studies on the Substances Concerning Plants and Plant Pathogenic Fungi

植物及植物病原真菌相关物质的化学研究

基本信息

批准号：
63303013
负责人：
IRIE Hiroshi
金额：
$ 8.58万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

Each researcher of this research group has carried out the basic investigation on the structure elucidation and the synthetic work of the natural products. Some of them carried out the problems concerning the organic substances which have novel biological activities in plant pathology field. Thus, lrie's group has accomplished the synthesis of compounds toxic to Japanese white pear and revealed the structure-toxicity relationship of the toxins and also accompilshed the synthesis of a self-inhibitor to germination of plant pathogenic fungus. Tsuda's group has been carrying on the synthetic work on antifungus compound and vermicides. Mayama's group has been doing the precise investigation on phytoalexin which are produced in oat infected with fungus. And his group also has made their effort to confirm the presence of the elicitors which lay between plant and fungus cell, when the plants were infected with fungus. Uemura's group has been carrying out the isolation and structure elucidation work on marine natural products which have the unique biological activities. Yoshimoto's group has been carrying out the isolation work of enzymes from mushrooms, which have specific activity as endo-prolinase, and aiming at an ample supply of the enzymes using bio-technology. Ohfune's group are carrying out the synthetic work of peptides using the method developed by themselves. Other researchers of this group are carrying out synthetic work on the compounds available to biological tests and basic reserch work to develop the new synthetic methods. Each group has obtained the attractive results and found useful methods for the chemistry of natural products.

本课题组的各位研究人员均开展了天然产物的结构解析和合成工作的基础研究。其中一些人在植物病理学领域开展了有关具有新生物活性的有机物质的问题。由此，Irie课题组完成了对日本白梨有毒的化合物的合成，揭示了毒素的结构-毒性关系，还完成了植物病原真菌萌发自抑制剂的合成。津田的研究小组一直在进行抗真菌化合物和杀虫剂的合成工作。真山的研究小组一直在对感染真菌的燕麦中产生的植物抗毒素进行精确研究。他的团队还努力确认当植物感染真菌时，植物和真菌细胞之间存在诱导子。上村教授课题组一直致力于对具有独特生物活性的海洋天然产物进行分离和结构解析工作。吉本课题组一直在从蘑菇中分离出具有内切脯氨酸酶特异活性的酶，并致力于利用生物技术充分供应这些酶。 Ohfune团队正在利用他们自己开发的方法进行肽的合成工作。该小组的其他研究人员正在对可用于生物测试的化合物进行合成工作，并开展基础研究工作以开发新的合成方法。每个小组都获得了引人注目的结果，并找到了天然产物化学的有用方法。