Experimental and theoretical study of hydrodynamics of solid particle transport in small scale

小尺度固体颗粒输运的流体动力学实验与理论研究

• 批准号: RGPIN-2017-05272
• 负责人: Ahmadi, Ali
• 金额: $ 1.68万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=752698
• 关键词: Experimental; theoretical; study; hydrodynamics; solid

The manipulation of solid particles in small scales has numerous applications including blood cell counting in hematology labs, fabrication of organs for implants and drug discovery, removal of bacteria from drinking water and monitoring particulate matter concentrations in air pollution. The efficiency of many of these applications strongly depends on the interaction of the particles with the surrounding fluid. The characterization of these interactions, however, becomes more challenging due to the decreased length and time scales in these miniaturized technologies.The proposed research program will focus on the theoretical and experimental aspects of the solid particle transport in rapidly changing small scale flows with direct application in the field of bio-printing. Bio-printing technologies have emerged to address the growing need for developing living tissue constructs that mimic the behaviour of the human body, and can be used for drug development or fabrication of functioning organs. As a new generation of bio-printers, inkjet printers have been utilized for controlled dispensing of living cells and biomaterials into specific patterns designed by computers. However, current inkjet bio-printers lack consistency, and face other problems including frequent nozzle clogging. The proposed program will fundamentally address the above mentioned challenges through the study of cell transport within the inkjet nozzles and microfluidic channels. In particular, a high speed imaging setup and numerical model will be developed to characterize the performance of inkjet cell printing systems. To increase the inkjet cell printing reliability, the use of viscoelastic bio-inks will be explored; the effects of rheological manipulation of bio-inks on the cell printing consistency will be studied. The fundamental knowledge of this novel research program can be applied in the development of technologies for handling solid particles in the small scale. These technologies will strengthen Canada's position as a leading country in advanced manufacturing and biotechnology fields. The HQP that will be trained in this program will be well suited to join the growing job market of these respective industrial fields.

小规模固体颗粒的操纵有许多应用，包括血液学实验室中的血细胞计数、植入器官的制造和药物发现、去除饮用水中的细菌以及监测空气污染中的颗粒物浓度。许多这些应用的效率很大程度上取决于颗粒与周围流体的相互作用。然而，由于这些小型化技术中长度和时间尺度的缩短，这些相互作用的表征变得更具挑战性。拟议的研究计划将重点关注快速变化的小规模流中固体颗粒输运的理论和实验方面以及直接应用在生物打印领域。生物打印技术的出现是为了满足开发模仿人体行为的活体组织结构日益增长的需求，并可用于药物开发或功能器官的制造。作为新一代生物打印机，喷墨打印机已用于将活细胞和生物材料受控分配成计算机设计的特定图案。然而，目前的喷墨生物打印机缺乏一致性，并面临喷嘴频繁堵塞等其他问题。拟议的计划将从根本上解决上述挑战，通过研究喷墨喷嘴和微流体通道内的细胞传输。特别是，将开发高速成像装置和数值模型来表征喷墨单元打印系统的性能。为了提高喷墨细胞打印的可靠性，将探索使用粘弹性生物墨水；将研究生物墨水的流变操作对细胞打印一致性的影响。这项新颖研究计划的基础知识可应用于开发小规模处理固体颗粒的技术。这些技术将巩固加拿大作为先进制造和生物技术领域领先国家的地位。将在该计划中接受培训的总部人员将非常适合加入这些各自工业领域不断增长的就业市场。