Synthesis and Structure-Function Studies of the Glycoprotein Adiponectin

糖蛋白脂联素的合成及结构功能研究

• 批准号: LP150100308
• 负责人: Prof Richard Payne
• 金额: $ 21.23万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-02-01 至 2019-02-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100308
• 关键词: Synthesis; Structure; Function; Studies; Glycoprotein

This project aims to understand the role of carbohydrate modifications on the structure and function of the fat cell-derived hormone adiponectin, which has shown protective effects against obesity, type 2 diabetes and cardiovascular disease. Advancing knowledge of the molecular mechanisms that regulate fat is crucial to unravelling the processes involved in the development of these diseases. The project plans to use novel synthetic technologies to access a library of adiponectins with defined patterns of carbohydrates attached to the peptide backbone, thus potentially enabling detailed dissection of the role of these modifications on structure, cell signalling and insulin sensitising activities.

该项目旨在了解碳水化合物修饰对脂肪细胞衍生的激素脂联素的结构和功能的作用，该脂肪蛋白显示出针对肥胖症，2型糖尿病和心血管疾病的保护作用。促进对调节脂肪的分​​子机制的了解对于揭示这些疾病发展所涉及的过程至关重要。该项目计划使用新颖的合成技术来访问具有连接到肽主链的碳水化合物模式的脂联素库，从而有可能详细解剖这些修饰在结构，细胞信号传导和胰岛素敏化活动中的作用。