Study of anastomotic neointimal hyperplasia after vascular prosthesis implantation. Its mechanism and prevention.

人工血管植入后吻合口新生内膜增生的研究。

基本信息

批准号：
03670575
负责人：
SAKUMA Makoto
金额：
$ 0.51万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670575/
关键词：
Vascular prostheses Vascular grafting Neointimal hyperplasia Graft occlusion Graft patency Laser anastomosis Antiplateled drug 代用血管移植血行再建内膜肥厚組織適合性 arrificial graft vas oular prosibesis neointimal hyperplasia arterial reco

项目摘要

Anastomotic neointimal hypertrophy (ANH) is suggested to be a contributing factor of last graft occlusion. To asess and to prevent ANH,five kind of small caliber grafts, polyurethane (PUG), expanded polytetrafluoroetylene (ePTFE) with 30,50 and 90 micron of fibrile length, and autovein graft (AV) were implanted in dog and pathological observation was performed by light microscopy and SEM.Cmulutative patency rate 3 months after implantation was 50% and ANH was occured in 27% of 26 grafts. ANH was markedly in PUG and was minimal in AV but there was no significant different of thickening rate between the five groups. Compareing anastomotic method of laser with suture, there was no different of thickening rate between the two method but laser anastomosis was seemed to be minilal ANH with good healing of he intima. Laser anastomosis is suggested to prevent ANH.To asess the influence of drug for preventing ANH,antiplatelet drug was administrated to the dog after graft implantation. Graft patency of the drug treatening group was higher than the control group but there was no significant difference of thickening rate between the drug treatening group and the control group. These results suggest that the antiplatelet drug is not effective to prevent ANH.

吻合的新内膜肥大（ANH）被认为是最后一次移植闭塞的因素。为了预防和预防ANH，将五种小口径移植物，聚氨酯（PUG），膨胀的聚氟甲基烯（EPTFE）植入了30,50和90微米的纤维长度，并植入了自动卵石植物（AV），并植入了狗和病理学观察中通过光学显微镜和SEM。植入后3个月的缝合通畅率为50％，在26个移植物中有27％发生ANH。 ANH明显在哈巴狗中，在AV中很少，但是五组之间的增厚速率没有显着不同。比较激光的吻合方法与缝合线相比，两种方法之间的增厚速率没有什么不同，但是激光吻合术似乎很小，并且在intima上可以很好地愈合。建议激光吻合术可防止ANH。为预防ANH的药物的影响，在移植后将抗血小板药物施用给狗。药物治疗组的移植物通畅性高于对照组，但是药物治疗组和对照组之间的增厚率没有显着差异。这些结果表明，抗血小板药物对预防ANH无效。