MALDI-TOF-TOF Mass Spectrometer

MALDI-TOF-TOF质谱仪

• 批准号: 524610847
• 金额: --
• 依托单位: Martin-Luther-Universität Halle-Wittenberg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/524610847?language=en
• 关键词: MALDI; TOF; Mass; Spectrometer

Modern polymer analysis requires high-resolution mass spectrometric techniques to analytically record the complexity of these molecules, both during synthesis and during their degradation. This applies, for example, to the sequence within polymer chains, the chain length (both in the case of synthetic and biological polymers), as well as the analysis of the chain structures, being of great importance in the context of the current SFB initiatives as well as the planned excellence initiative, where omplex structure/property relationships are to be analyzed. The MALDI-TOF-TOF MS applied for here replaces a device purchased 15 years ago, which has already exceeded its service life and is noticeable due to high repair/maintenance costs as well as reduced usability and already relatively low measuring accuracy. The newly purchased device has more modern technology, such as the TOF/TOF technology for the analysis of complex fragmentations and thus a more precise and detail-oriented structural analysis. MS analysis of polymers/macromolecules via MS spectroscopy, especially MALDI-TOF, is a standard methodology with great potential for expansion. It enables the determination of the exact molecular weight of high-molecular molecules, in resolution down to the isotope pattern, so that precise analysis of the composition, the chemical identity and the sequence of macromolecules is possible. This makes complex substance structures accessible both in terms of chemical structure and chemical-biological degradation, and the underlying mechanisms are understandable and therefore controllable. The device is directly integrated into the ongoing SFB TRR 102, the ongoing graduate school, as well as the ongoing third-party funded activities embedded in the group. The device is strategically central for the requested SFB initiatives as well as the SFB preliminary application SFB-TRR 382 as well as the planned application outline within the framework of the Federal Excellence Initiative. These initiatives are part of the planned excellence program that is being developed transregionally with the universities of Jena/Potsdam/Bayreuth. The aim of this program should be directed towards new aspects of the sustainability of polymers. In addition, research activities are to be located around the new Center of Sustainable Materials (CSME), wherein the MALDI-TOF-TOF will be integrated into the planned analytical unit.

现代聚合物分析需要高分辨率的质谱技术，以分析合成期间和降解过程中这些分子的复杂性。例如，这适用于聚合物链内的序列，链长（在合成和生物学聚合物的情况下）以及对链结构的分析，在当前SFB计划的背景下以及计划的卓越倡议中非常重要，其中OMPEARITIATIVE，其中Omplex结构/财产关系将被分析。 MALDI-TOF-TOF-MS在这里申请了15年前购买的设备，该设备已经超过了其使用寿命，并且由于高维修/维护成本以及降低可用性和相对较低的测量准确性而引人注目。新购买的设备具有更现代的技术，例如用于分析复杂碎片的TOF/TOF技术，因此更精确，面向细节的结构分析。通过MS光谱法，尤其是MALDI-TOF对聚合物/大分子的MS分析是一种具有巨大扩展潜力的标准方法。它可以确定高分子分子的确切分子量，以归根于同位素模式，从而可以对组合物，化学身份和大分子的序列进行精确分析。这使得在化学结构和化学生物学降解方面都可以使用复杂的物质结构，并且基本机制是可以理解的，因此可以控制。该设备直接集成到正在进行的研究生院的正在进行的SFB TRR 102中，以及正在进行的第三方资助的活动中嵌入了该组中。该设备在策略上对于要求的SFB计划以及SFB初步申请SFB-TRR 382以及计划的应用程序概述在《联邦卓越倡议》的框架内。这些举措是计划中卓越计划的一部分，该计划正在与Jena/Potsdam/Bayreuth大学进行跨区域开发。该计划的目的应针对聚合物可持续性的新方面。此外，研究活动应位于新的可持续材料中心（CSME）附近，其中MALDI-TOF-TOF将集成到计划的分析单元中。