Comprehensive studies on age-related deficits in learning and memory in SAM

SAM 中与年龄相关的学习和记忆缺陷的综合研究

基本信息

批准号：
03404023
负责人：
TAKEDA Toshio
金额：
$ 19.97万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03404023/
关键词：
Senescence-Accelerated Mouse (SAM)Animal model Senescence Deficits in learning & memory Brain atrophy Reticular formation Fatty acid 脂肢酸食餌脂肪酸血液・脳バリア脳幹網様体大脳新皮質

项目摘要

deta / A4 arotein-like immunoreactivity was observed in the form of granular structures in various regions, including the medial septum, cerebral cortex, hippocampus, and so on. These increased in number with aging, predominantly in SAM-P/8 with deficits in lemory deficiThe severity of deficits in learning and memory closely correlated with the total area and number of vacuoles in magnocellular reticular formation (MGRF) of brain stem. MGRF lesioned SAM-R/1 mice showed a severe deterioration in passive avoidance tasks and an impairment in the acquisition stage of active avoidance performance.An inbred SAM-P/10 strain has been established as a model of agerelated brain atrophy. Morphometric studies showed that frontal cortex including prefrontal cortex, other neocortical regions, posterior piriorm cortex, anterior olfactory nucleus, amygdala, and caudate putamen were atrophy-prone regions. Shrinkage of the neuronal somata and loss of large neurons with age are unique for SAM-P/10, both of which bring about age-related atrophyAge-related changes in learning and memory skills of SAM-P/10 mice were investigated using a newly developed conditional avoidance retained the left-right turning discrimination in the T-maze and lost the ability to predict the forthcoming aversive shock by associating conditioned and unconditioned stimulus.

在各个区域，包括内侧隔膜，大脑皮层，海马等等，以颗粒结构的形式观察到DETA / A4芳族蛋白样免疫反应性。随着衰老的数量增加，主要在SAM-P/8中，而在学习和记忆中缺陷的缺陷缺陷与脑干的大细胞网状形成（MGRF）中的总面积和液泡数紧密相关。 MGRF病变的SAM-R/1小鼠在被动避免任务中表现出严重的恶化，并且在积极回避性能的采集阶段受损。已建立了近交SAM-P/10菌株作为变质脑萎缩的模型。形态计量学研究表明，包括前额叶皮层，其他新皮层区域，piriorm piriorm皮层，前嗅觉核核，杏仁核和念珠菌的pr虫是萎缩性区域。 SAM-P/10的神经元SOMATA的收缩和随着年龄的年龄的损失是独特的，这两者都使用新近研究了与年龄有关的与年龄相关的萎缩相关的学习和记忆技能的变化SAM-P/10小鼠的记忆技巧开发的有条件回避保留了T迷宫中左右转弯歧视，并通过关联条件和无条件的刺激而失去了预测即将发生的厌恶冲击的能力。