Development of Heat Generating Magnetic Materials for Hyperthermia and Application to Medical Treatment

热疗用磁性发热材料的研制及其在医疗中的应用

基本信息

批准号：
02559008
负责人：
MATSUI Masaaki
金额：
$ 9.02万
依托单位：
Nagoya university
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02559008/
关键词：
Interstitial heating hyperthermia heat generating materials Fe-Pt alloys Mg-Ca Ferrites Silane-coating eddy current loss hysteresis loss フェライトガラスコ-ティング FeーPt合金溶出試験

项目摘要

The implant materials for hyperthermia of cancer tissues were developed and the clinical investigations were performed. Results of the research are summarized as follows :1. The corrosion resistance of the Fe-Pt alloy implant material for hyperthermia, which has low Curie point and large heat generation through the eddy current loss, is larger than that of a stainless steel. However, when the implant was embedded in the tissue of the thigh of a rabbit, the dissolved Fe element was a little bit detected in the X-ray analysis(1.0 x 10^<-4> g/cm^2 month).2. In order to prevent the alloy elements from dissolving, the biocompatible compound SiO_2 was coated on the implant using silane and phosphorus acid. The coating improved the corrosion resistance remarkably.3. The powder samples of Fe-Pt alloys were prepared as a heat generation materials through magnetic hysteresis loss. The heat generation of the powder material was enough to be used for hyperthermia. A spray-drying method was developed for the SiO_2 coating of the powder particles.4. The ceramic materials of CaO-MgO-Fe_2O_3 system whose elements are all biocompatible were investigated as new powder implant materials for hyperthermia. It was found that the materials of x=0.525 for (MgO)_<1-x>(Fe_2O_3)_x and y=1.0 for (CaFe_4O_7)_<1-y>(MgFe_2O_4)_y have the large heat generation through hysteresis loss which is several times larger than that of Fe_3O_4. The curie points of the materials are lower than that of Fe_3O_4.5. The clinical treatment for brain tumors and tongue tumors were tried for several cases using Fe-Pt alloy implants. The effects of hyperthermia were remarkable, 45.5% for brain tumors and 100% for tongue tumors.

开发了用于癌症组织高温的植入物，并进行了临床研究。研究结果总结如下：1。 Fe-PT合金植入物材料的耐腐蚀性比不锈钢的质量较低，并且通过涡流损失较低。但是，当将植入物嵌入兔大腿的组织中时，在X射线分析（1.0 x 10^<-4> g/cm^2个月）中，溶解的Fe元件稍微检测到。为了防止合金元素溶解，使用硅烷和磷酸将生物相容性化合物SIO_2涂在植入物上。涂层可显着提高腐蚀性3。通过磁性磁滞损失，Fe-PT合金的粉末样品作为热产生材料制备。粉末材料的热产生足以用于高温。开发了用于粉末颗粒的SIO_2涂层的喷涂方法4。 CAO-MGO-FE_2O_3系统的陶瓷材料的元素都是生物相容性的。发现（MGO）_ <1-x>（Fe_2O_3）_x和y = 1.0的X = 0.525的材料对于（Cafe_4O_4）_ <1-y>（MGFE_2O_4）_y具有大量的热量损失，这是大量产生的较大的损失，这是比Fe_3o__4大的几倍。材料的库里点低于FE_3O_4.5的质量。使用Fe-PT合金植入物对脑肿瘤和舌头肿瘤进行临床治疗。热疗的作用非常明显，脑肿瘤的45.5％，舌肿瘤100％。