Development of new biocompatible magnetic materials and the application to hyperthermia of cancer

新型生物相容性磁性材料的开发及其在癌症热疗中的应用

基本信息

批准号：
08559007
负责人：
MATSUI Masaaki
金额：
$ 4.54万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

We have investigated the magnetic materials which is used for hyperthermia of cancer under the high frequency alternating magnetic field (H) . The hysteresis loss heat generation and Curie temperature (Tc) have been measured for several materials. The biocompatibility of materials has been taken into consideration. The summary is listed as follows.1) Magnetic properties and the heat generation of Mg-Fe-M-0 (M=Ti, Si, K, Ca) oxides was investigated. In the Mg_<1+x>Fe_<2-2x>Ti_x0_4 system, the Curie temperature (Tc) decreased with increasing x, from 635K for x=0.0 to 200K for x=0.5. The heat generation Q=16W/g for x=0.0 at H=100 Oe decreased to 3W/g for x=0.35 at room temperature. We found that the Ti substitution is best for hyperthermia.2) Ultra fine particles of Fe_3O_4 were made by the chemical method. The particles with diameter less than 2Onm showed the lower Tc than bulk (850K) . Tc decreased with decreasing the diameter and 660K for 5nm was achieved as minimum Tc. It is concluded that the decrease of diameter is an appropriate method to decrease the Tc.3) Ultra fine particles of Co wera investigated. It was difficult to obtain the Co particles with a diameter less than 2Onm. Tc of the particles with 2Onm in diameter was almost same to bulk value. Co particles are not appropriate for hyperthermia.4) Artificial metallic superlattices including Fe atomic layers were made. The minimum of Tc for alpha-Fe was 350K at 1.3 monolayer (ML) and that for gamma-Fe was 300K at 0.8 ML of Fe. It was concluded that such superlattices with ultra thin atomic layers has the appropriate Tc but could not be used for hyperthermia, because the quantity of production by one process is very small.

我们已经研究了在高频交替磁场（H）下用于癌症高温的磁性材料。磁滞损失产生和居里温度（TC）已针对几种材料进行测量。已经考虑了材料的生物相容性。该摘要列为如下。1）磁性特性和MG-FE-M-0（M = Ti，Si，K，Ca）氧化物的热量产生。在mg_ <1+x> fe_ <2-2x> Ti_x0_4系统中，随着x的增加，居里温度（TC）降低，从x = 0.0到x = 0.5的635k从x = 0.0到200k。 H = 100 OE的热量生成Q = 16W/g，x = 0.0在室温下x = 0.35降低至3W/g。我们发现TI取代最适合热疗。2）Fe_3O_4的超细颗粒是通过化学方法制成的。直径小于2onm的颗粒显示出比散装（850k）低的TC。 TC随着直径降低而降低，5nm的TC作为最小TC实现了5nm。结论是，直径的减少是减少TC的合适方法。3）已研究的CO WERA的超细颗粒。很难获得直径小于2onm的CO颗粒。直径2onm的颗粒TC几乎与大容量值相同。 CO颗粒不适合热疗。4）制作了包括Fe原子层在内的人造金属晶格。 Alpha-FE的最低TC为1.3单层（ML）350K，而伽马-FE的TC为0.8 ml的Fe为300K。得出的结论是，具有超薄原子层的这种超晶格具有适当的TC，但不能用于高温，因为一个过程的生产量很小。