Evaluation of liver graft viability in human liver transplantation.

人肝移植中肝移植物活力的评估。

• 批准号: 02044086
• 负责人: OZAWA Kazue
• 金额: $ 7.04万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02044086/
• 关键词: Liver Transplantation; Initial Non-Functioning Liver; Viability of The Liver Graft; Arterial Ketone Body Ratio; 血中ケトン体比

Viability of the donor liver was assessed with regard to the early postoperative survival in human liver transplantations from 40 brain-dead donors in Hannox-er Medical College (MHH) and 31 living donors in Kyoto University (KYOTO) by measuring arterial ketone body ratio (AKBR). Of 40 cases harvested from brain-dead patients in MHH, 35 cases survived the first week after operation, but 5 cases developed the initial nonfunction of the transplanted graft (INF) and died within the first week. The mean valued of AKBR of each group were 1.10<minus-plus>0.10 and 0.44<minus-plus>0.10, respectively (p<0.01). A-I (BR of the 5 INF cases were all below 0.7. Of 31 cases harvested from the living donors in KYOTO, all survived the first week, and AKBR values of them were almost above 1.0 with the mean value of 1.85<minus-plus>0.23. In total of 66 cases, survival rates of the cases whose AKBR were higher than 0.7 was significantly higher than that of the cases whose AKBR were below 0.7 (100% v. s. 42%, p<It is demonstrated that AKBR can be the effective scientific scale to evaluate the viability of the donor liver.

通过测量动脉酮体比率（AKBR），评估了供体肝脏的生存力，以对汉诺克斯-ER医学院（MHH）的40名脑死亡供体的早期术后生存和31位京都大学（京都大学）活着的捐助者的生存能力进行评估。在MHH中，在手术后的第一周幸存了35例脑死患者的40例病例中，但有5例患者出现了移植的移植物（INF）的最初无函数，并在第一周内死亡。每组AKBR的平均值分别为1.10 <minus-plus> 0.10和0.44 <minus-plus> 0.10（p <0.01）。 A-1（5例INC案例中的BR均低于0.7。在京都从京都的31例案例中均低于第一周的生存，它们的AKBR值几乎高于1.0，平均值为1.85 <minus-plus> 0.23。在66个案例中，其AKBR的存活率高于0.7（akbr）的生存率高于0.7（n.7）。 42％，p <可以证明AKBR可以是评估供体肝脏生存能力的有效科学量表。

项目成果

A.Tanaka,et al.: "The role of enhanced mitochondrial phosphorylation in rat liver transplantation." J.Surg.Res.,.

A.Tanaka 等人：“增强线粒体磷酸化在大鼠肝移植中的作用。”

K. Ozawa, et al.: "Linear correlation between acetoacetate/B-hydroxybutyrate in arterial blood and oxidized flavoprotein/reduced pyridine nucleotide in freeze-trapped human liver tissue." Lancet.

K. Ozawa 等人：“动脉血中的乙酰乙酸/B-羟基丁酸与冷冻捕获的人肝组织中的氧化黄素蛋白/还原吡啶核苷酸之间的线性相关性。”

K. Ozawa: "Liver resection of redox theory." Current advances in digestive surgery in Japan.

K. Ozawa：“氧化还原理论的肝切除术。”

K. Ozawa, et al.: "Experience with 225 hepatic resections for hepatocellular carcinoma over a 4-year period." Am. J. Surg.161. 677-682 (1991)

K. Ozawa 等人：“4 年期间进行 225 例肝细胞癌肝切除术的经验。”

A. Tanaka, et al.: "The role of enhanced mitochondrial phosphorylation in rat liver transplantation." J. Surg. Res.

A. Tanaka 等人：“增强线粒体磷酸化在大鼠肝移植中的作用。”