Investigations into the antibacterial mechanism of action of cannabidiol

大麻二酚抗菌作用机制的研究

• 批准号: DP240102291
• 负责人: Prof Mark Blaskovich
• 金额: $ 41.37万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102291
• 关键词: Investigations; into; antibacterial; mechanism; action

Cannabidiol (CBD) comes from a set of naturally occurring compounds, with a range of applications in mainstream culture. We have recently reported that CBD has excellent antimicrobial properties, with the ability to kill bacteria. This project aims to understand how CBD works by examining CBD-bacterial interactions at a genetic and molecular level. By understanding how CBD acts on and within bacterial cells, we can create fundamental new knowledge that could lead to the design of improved analogs of CBD to that can treat bacterial infections. As a much-needed completely new antibiotic class, this will lead to significant benefits, supporting Australia's National Strategy to combat the challenges posed by antimicrobial resistance.

大麻二醇（CBD）来自一组天然发生的化合物，并在主流培养中具有一系列应用。我们最近报道说，CBD具有出色的抗菌特性，具有杀死细菌的能力。该项目旨在通过在遗传和分子水平上检查CBD - 细菌相互作用来了解CBD的工作方式。通过了解CBD在细菌细胞上的作用和在细菌细胞内的作用，我们可以创建基本的新知识，这可能会导致对CBD的改进类似物的设计，从而可以治疗细菌感染。作为一个急需的全新抗生素类别，这将带来巨大的好处，这支持澳大利亚国家战略应对抗菌耐药性带来的挑战。