Investigations into the antibacterial mechanism of action of cannabidiol

大麻二酚抗菌作用机制的研究

• 批准号: LP200100418
• 负责人: Prof Mark Blaskovich
• 金额: --
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-24 至 2022-06-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP200100418
• 关键词: Investigations; into; antibacterial; mechanism; action; Investigations; into; antibacterial; mechanism; action

This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead to significant benefits, including high impact publications, additional collaborations with industrial partner Botanix, and a new class of antibiotics to overcome antibiotic resistance.

该项目旨在了解化合物大麻二酚如何通过检查其与遗传和分子水平的细菌的相互作用来杀死细菌。这项研究至关重要，因为大麻二酚的未来发展和改进的类似物的设计是基于了解其工作原理的基础。 预期的结果包括对大麻二酚如何与细菌相互作用的第一个详细理解。这将带来巨大的好处，包括高影响出版物，与工业合作伙伴Botanix的额外合作以及一类新的抗生素来克服抗生素耐药性。