Selective Catalytic Hydrogenation and Functionalization of Polyenes

多烯的选择性催化氢化和官能化

• 批准号: 556312-2020
• 负责人: Lundgren, Rylan
• 金额: $ 4.24万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=706265
• 关键词: Selective; Catalytic; Hydrogenation; Functionalization; Polyenes

The goal of this research collaboration is to develop new chemical processes and to understand how feedstock small molecules can be converted into high value products by catalysis. Three distinct transformations of practical and fundamental importance are targeted. Each target poses a challenge to known methods in homogenous catalysis. The products sought to be made can readily undergo a myriad of side-reactions (over reduction, poly addition, isomerization), thus a high level of kinetic selectivity must be achieved by tailored reaction conditions and transition metal catalysts. The successful development of these processes should lead to more broad applications in sustainable chemical manufacturing. We plan a similar approach to the individual processes, consisting of initial broad screening of reaction conditions and catalysts to discover "hit" conditions followed by more careful reaction optimization and catalyst structure-reactivity studies, and finally demonstration of process scalability and generality.

这项研究合作的目标是开发新的化学工艺，并了解如何通过催化将原料小分子转化为高价值产品。我们的目标是实现三个具有实际意义和根本重要性的不同转变。每个目标都对均相催化的已知方法提出了挑战。所要制造的产品很容易发生大量副反应（过度还原、加聚、异构化），因此必须通过定制的反应条件和过渡金属催化剂来实现高水平的动力学选择性。这些工艺的成功开发应该会在可持续化学制造中带来更广泛的应用。我们计划对各个工艺采用类似的方法，包括最初广泛筛选反应条件和催化剂以发现“命中”条件，然后进行更仔细的反应优化和催化剂结构反应性研究，最后演示工艺的可扩展性和通用性。