Connectomes arising: linking structure and function in neocortical wiring.

连接组的出现：连接新皮质接线中的结构和功能。

• 批准号: DP240102384
• 负责人: A/Prof Rodrigo Suarez
• 金额: $ 40.98万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-07-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102384
• 关键词: Connectomes; arising; linking; structure; function

The cerebral cortex underpins human cognition, yet exactly how it becomes connected is unknown due to a lack of live developmental assays. We overcome this using prematurely born marsupials, which allow to study cortical development from embryo-like stages with remarkable resolution. This project will study how neural activity arises as the first connections are formed, and link functional and structural networks across development in vivo. Experimental manipulations of activity, and computational models will discover developmental rules for precise wiring of cortical connections. Benefits include new methods to study cortical development, and outlining electrical, molecular and neuroanatomical signatures of early mammalian brain formation.

大脑皮层是人类认知的基础，但由于缺乏实时发育分析，其具体如何连接尚不清楚。我们使用早产的有袋动物克服了这个问题，这使得我们能够以惊人的分辨率研究胚胎阶段的皮质发育。该项目将研究神经活动在首次连接形成时如何产生，并在体内发育过程中连接功能和结构网络。对活动和计算模型的实验操作将发现皮层连接精确布线的发育规则。好处包括研究皮质发育的新方法，以及概述早期哺乳动物大脑形成的电学、分子和神经解剖学特征。