Effects of hormones on enzynoes in rat nephron segment.-For the protection of isclemmic acute renal failure-

激素对大鼠肾单位段酶的影响-对缺血性急性肾功能衰竭的保护-

• 批准号: 61570306
• 负责人: TOMITA Kimio
• 金额: $ 1.34万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570306/
• 关键词: Na-K-ATPase; Vasopressin; Tubular enzzme; Kininase; Anyiotensin-I converting enzyme; Aldosterone; 急性腎不全; 甲状腺ホルモン; 集合尿細管; レニン活性; ACE活性

Effects of vasopressin, aldosteronl on enzymes were investigated in rat nepbron segments.Vasopressin stimulated Na-K-ATPase activity in rat cortical collecting duct. The stimulative effects were detected following the treat ment about 3 days. Simian stimulation occured 7th day treat ment's.Kininase may be one of the rate limiting factor in the kallikrein-kimin system. Kininase was also invert・gcted along the nepluon. Kinimase was detected in medullary Collecting duct. The acticity acereased following the trecut ment of aldosterone. for 3.7 days.These hormcrce may have protective effect eithen by stimulating Na-K-ATPase or by decreasing kininase.

在大鼠尼普龙片段中研究了加压素，醛固酮对酶的作用。在大鼠皮质收集管道中，呼吸链蛋白刺激了Na-k-ATPase活性。在治疗大约3天后，检测到刺激作用。发生的第7天治疗方法发生了猿猴刺激。金酶可能是kallikrein-kimin系统中的速率限制因素之一。激酶也沿着nepluon反转。在髓质收集管中检测到酶酶。该障碍等于醛固酮的训练。在3.7天内。这些角可能通过刺激Na-k-ATPase或减少激酶来保护效果。

项目成果

Kimio Tomita: Kidney International. 31. 289 (1987)

富田公夫：肾脏国际。

Kimio Tomita;Akira Owada;Yasuhiko Iino;Naoki Yoshiyama;Tatsuo Shiigai: American Journal of Physiology. 253. F874-F879 (1987)

Kimio Tomita；Akira Owada；Yasuhiko Iino；Naoki Yoshiyama；Tatsuo Shiigai：美国生理学杂志。

Kimio Tomita, Akira Owada, Yasuhiko Iino, Naoki Yoshiyama, Tatsuo Shugai.: "Effect of vasopressin on Na-K-ATPase activity in rat cortical collecting duct." American. Journal of physiology. 253. F874-F879 (1987)

Kimio Tomita、Akira Owada、Yasuhiko Iino、Naoki Yoshiyama、Tatsuo Shugai.：“加压素对大鼠皮质集合管 Na-K-ATP 酶活性的影响。”