An equivalent cardiac source for the anisotropic muscle based on the bidomain theory and its application to the inverse problem in electrocardiology

基于双域理论的各向异性肌等效心源及其在心电学逆问题中的应用

基本信息

批准号：
60570409
负责人：
YAMASHITA Yasuo
金额：
$ 1.15万
依托单位：
Tokai University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570409/
关键词：
Bidomain model Anisotropy of heart muscle Transmembrane potential 心電図逆方向問題

项目摘要

We developed an equivalent electric source for anisotropic cardiac muscle based on the bidomain (bisyncytia) model and then discussed a method of reconstructing (macroscopic) transmembrane potentials over the heart surface.First, we gave the extracelluar potential in a bounded inhomogeneous volume conductor in the form of an integral equation. It is possible to calculate the field potential from the transmembrane potential distribution in the heart, with a knowledge of geometrical property of muscle fibers as well as anisotropic conductivity of the heart muscle. Second, we discussed the method of estimating the (in situ) transmembrane potentials from the body surface map using the above equation. It is predicted that, if ratios of intracellular to extracellular conductivity along all directions are equal, the field potentials can be determined only using surface integral of the transmembrane potentials over the heart surface since the volume integral arising from the tissue anisotropy of cardiac muscle vanishes. Therefore, in that case, the in situ transmembrane potential distribution on the heart surface can be calculated uniquely from potential maps measured on the body surface.We are developing a procedure of calculating the in situ transmembrane potentials from the body surface maps. It is expected that the in situ transmembrane potentials will be most effective in diagnosing of infarcted area and size since it is directly related to electric activity of heart muscle cells.

我们开发了基于双域（Bisyncytia）模型的各向异性心肌肌肉的等效电源，然后讨论了一种重建（宏观）跨膜电位的方法。有可能了解心脏中跨膜电位分布的田间电位，并了解心脏肌肉的肌肉纤维的几何特性以及心肌的各向异性电导率。其次，我们讨论了使用上述方程式从身体表面图估算（原位）跨膜电位的方法。据预测，如果沿所有方向的细胞内与细胞外电导率的比率相等，则只能使用跨膜电位的表面积分在心脏表面上确定，因为由于心脏肌肉的组织各向异性产生的体积积分而来。因此，在这种情况下，可以从体面上测得的电位图唯一计算出心脏表面上的原位跨膜电位分布。我们正在开发一种从人体表面图中计算原位跨膜电位的过程。预计原位跨膜电位将在诊断梗塞区域和大小上最有效，因为它与心肌细胞的电活动直接相关。