In vivo imaging of viscoelasticity and hardness of biological soft tissue using ultrasound.

使用超声对生物软组织的粘弹性和硬度进行体内成像。

基本信息

批准号：
05680766
负责人：
YAMASHITA Yasuo
金额：
$ 1.28万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05680766/
关键词：
Local Strain Tensor Tissue Elasticity Tissue Hardness Local Tissue Deformation Relative Shear Modulus Ultrasonic Imaging In Vivo Imaging 超音波生体組織の硬さ局所歪テンソル変位分布変位歪生体組織の粘弾性

项目摘要

Changes in tissue elasticity are related to diffuse disease processes of living soft tissue. The goal of this study is to characterize tissue elasticity based on ultrasonic measurement of displacement and strain when the primary cardiac pulsation or the external mechanical force is applied to the soft tissue. A model is presented for the changes in tissue elasticity as a change of internal strain tensor, which results in variation in the Young's or shear modulus of elasticity. Mesurements are performed using real-time ultrasound and the sequences of RF echo signal returned from tissue are digitized to estimate local tissue displacement. In this paper the 2-dimensional distribution of internal displacement is estimated using the spatio-temporal derivative of RF echo envelope signals, from which components of internal strain tensor are computed. Experiments on tissue mimicking phantoms indicate that 2-dimensional fields of components of strain tensor can be estimated with the spatial resolution of 8mm*8mm. The distribution of the relative shear modulus based on strain images is reconstructed. In experiments with living soft tissue, such as liver in vivo, the relative shear modulus is large in less elastic regions. The elasticity of soft tissue can be characterized as the relative shear modulus computed from the local strain tenpor observed in the received RF echo signals.

组织弹性的变化与活软组织的弥漫性疾病过程有关。这项研究的目的是在将主要心脏脉动或外部机械力应用于软组织时，基于位移和应变的超声测量来表征组织弹性。为内部应变张量的变化提出了一个模型，以改变组织弹性的变化，从而导致年轻的弹性或剪切模量的变化。使用实时超声进行介绍，并将从组织返回的RF回声信号的序列数字化以估计局部组织位移。在本文中，使用RF回声包膜信号的时空导数估算了内部位移的二维分布，从中计算内部应变张量的组件。模仿幻影的组织实验表明，可以通过8mm*8mm的空间分辨率估算应变张量的二维场。基于应变图像的相对剪切模量的分布已重建。在使用活体内的活软组织的实验中，相对剪切模量在较小的弹性区域中很大。软组织的弹性可以表征为从接收到的RF回声信号中观察到的局部菌株tonpor计算出的相对剪切模量。