Development of ^<99m>Tc-complexes for imaging cancer metastasis

用于癌症转移成像的^<99m>Tc复合物的开发

基本信息

批准号：
09672190
负责人：
NAKAYAMA Morio
金额：
$ 1.92万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672190/
关键词：
Hydroxamic acid Cancer ^<99m>Tc ヒドロキサムアミド ^<99m>Tc錯体

项目摘要

We planed to develope the imaging agent for cancer metastasis by the two approaches as followes :(1) Production of ^<99m>Tc-labded compounds by the introduction of ^<99m>Tc-complexes to the antibody or polypeptide that shows high affinity for the antigen or receptor on cell membrane of primary canncer and the importantfactor for angiogenesis(2) Development of ^<99m>Tc-coinplexes that show high affinity for tumor.Since ^<99m>Tc-iagnostic agents essetially contains the ^<99m>Tc by the coordinate bond, the behavior of ^<99m>Tc in vivo is very influenced by the equilibrium state involving the ligand and ^<99m>Tc. Accordingly, the present ^<99m>Tc-radiopharmaceuticals have developed on the base of the strategy described above (1), namely many researchers developed the various ligand systems that form the higly stable ^<99m>Tc-complexes. However, the ligand system availabe for the clinical use has not been completed.On the other hand, though it is known that seine polynucleus metal complexes show high affinity for tumor, the systematic research has never been carried out.In this study, We selected the two ligand systems to perform the duvelopment of ^<99m>Tc-complexes for imaging cancer metastasisboth by the two way. One is hydroxamamide ligand system which form stable ^<99m>Tc-complex. The other is hydroxamica acid ligand system which have the possibility for the formation of the polynucleous ^<99m>Tc-complexes. The difference in ligand system resulted in the change of the properties of ^<99m>Tc-complex and the behavior of ^<99m>Tc in vivo.

We planed to develope the imaging agent for cancer metastasis by the two approaches as followes :(1) Production of ^<99m>Tc-labded compounds by the introduction of ^<99m>Tc-complexes to the antibody or polypeptide that shows high affinity for the antigen or receptor on cell membrane of primary canncer and the importantfactor for angiogenesis(2) Development of ^<99m> tc-coinplexes对肿瘤表现出很高的亲和力。 ^<99m> tc-iagnostic ventents在本文上通过坐标键包含 ^<99m> tc，体内 ^<99m> tc tc的行为受到了均衡状态的影响，受到了Ligilibrium的均衡状态，并受到LIGAND的均衡状态和 ^99m> tc的均衡状态。因此，目前的 ^<99m> tc-radiopharmaceuticals已在上述策略的基础上开发了（1），即许多研究人员开发了形成稳定稳定的 ^<99m> tc-compelxes的各种配体系统。 However, the ligand system availabe for the clinical use has not been completed.On the other hand, though it is known that seine polynucleus metal complexes show high affinity for tumor, the systematic research has never been carried out.In this study, We selected the two ligand systems to perform the duvelopment of ^<99m>Tc-complexes for imaging cancer metastasisboth by the two way.一个是羟胺胺配体系统，形成稳定的 ^<99m> Tc-complex。另一个是羟基酸配体系统，它具有形成多核 ^<99m> tc-complexes的可能性。配体系统的差异导致 ^<99m> tc-complex的性质变化以及体内 ^<99m> tc的行为。