Growth factor of hair cell regeneration in auditory epithelium and cochlear nucleus

听觉上皮和耳蜗核毛细胞再生的生长因子

• 批准号: 09671775
• 负责人: SAKAGAMI Masafumi
• 金额: $ 1.98万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671775/
• 关键词: auditory epithelium; cochlear nucleus; regeneration; growth factor; adhesion molecule; genesis; acoustic trauma; 鳥類; 神経伝達物質; 再生; コルチ器

Growth factors and adhesion molecules of embryogenesis and regeneration, because both are similar in auditory epithelium. By immunohistochemistry neurite growth factor (NOF) was expressed in acoustic ganglion and basal membrane at gestational and immmature stages. New adhesion molecule, gicerin, was expressed in auditory epithelium and acoustic ganglion at immature stage, and in the area of active cell proliferation of regenerative epithelium after acoustic trauma. Gicerin may be associated with cell proliferation in the auditory epithelium, and play a role in neurite extension of the acoustic ganglion cells in conjunction with NOF.Highly polysialylated neural adhesion molecule (NCAM-H) was observed in nerve fibers of auditory epithelium and acoustic ganglion at gestational stage. It was also observed at acoustic ganglion after birth. It is suggested that NCAM-H specifically regulates the afferent nerve fibers' growthand synaptogenesis with hair cells during inner ear development and may be associated with neuronal plasticity.

胚胎发生和再生的生长因子和粘附分子，因为在听觉上皮上都相似。通过免疫组织化学神经突生长因子（NOF）在妊娠和免疫阶段的声学神经节和基底膜中表达。新的粘附分子Gicerin在不成熟阶段的听觉上皮和声学神经节中表达，在声学创伤后再生上皮细胞的活性细胞增殖区域。甲状腺素可能与听觉上皮的细胞增殖有关，并在声学神经节细胞的神经突扩展中与NOF。在妊娠期。出生后在声学神经节上也观察到它。建议NCAM-H特异性调节传入神经纤维在内耳发育过程中与毛细胞的生长和突触发生，并且可能与神经元可塑性有关。

项目成果

Adachi O, Akira S, et al: "Targeted disruption of the MyD88 gene results in loss of IL-land IL-18 mediated function" Immunity. 9. 143-150 (1998)

Adachi O、Akira S 等人：“MyD88 基因的靶向破坏导致 IL-1 和 IL-18 介导的功能丧失”免疫。

Kajikawa H, Umemoto M,et al: "Expression of highly polysialylated NCAM(NCAM-H)in developing and adult chicken auditory organ" Hear Res. 103. 123-130 (1997)

Kajikawa H、Umemoto M 等人：“高度多唾液酸化的 NCAM (NCAM-H) 在发育中和成年鸡听觉器官中的表达” Hear Res。

Fukazawa K, Sakagami M et al.: "Regeneration of epithelial cells of the maxillary sinus mucosa in chronic sinusitis" Med Electron microsc. 31. 10-15 (1998)

Fukazawa K、Sakagami M 等人：“慢性鼻窦炎中上颌窦粘膜上皮细胞的再生”Med Electron microsc。

Kajikawa, Umemoto M,et al.: "Expression of neurite outgrowth factor and gicerin during inner ear development and hair cell regeneration in the chick" J Neurocytol. 26. 501-509 (1997)

Kajikawa、Umemoto M 等人：“小鸡内耳发育和毛细胞再生过程中神经突生长因子和甘油的表达”J Neurocytol。

Kajikawa H, Umemoto M,et al: "Expression of neurite outgrowthfactor and gicerin during inner ear development and hair cell regeneration in the chick" J Neurocytol. 26. 501-509 (1997)

Kajikawa H、Umemoto M 等人：“小鸡内耳发育和毛细胞再生过程中神经突生长因子和甘油的表达”J Neurocytol。