On interaction between genetic factors and environmental factors.

论遗传因素与环境因素的相互作用。

• 批准号: 09670367
• 负责人: HIGURASHI Makoto
• 金额: $ 1.92万
• 依托单位: Tokyo Kasei University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670367/
• 关键词: Blue Light; Newborn; Down Syndrome; Sister chromatid exchange; 百日咳菌; 高発がん性; 老化; 免疫異常; 退行

This study determines whether irradiation by blue or green light has an adverse effect on the DNA of Down syndrome (DS) cells by examining the sister chromatid exchanges (SCE) frequency of peripheral lymphocytes obtained from five neonates with DS and five karyotypically normal neonates (control). Lymphocytes in Go of the cell cycle were irradiated with blue or green fluorescent light for 1, 2, 4 or 6 h, and then cultured using a conventional method. Our results revealed that the induction of SCEs per cell in both groups increased in a dose-dependent manner, although more SCEs were respectively induced by the blue light. In addition, after 6h of blue light irradiation, the net-induced SCEs in the DS groups were higher than those in the control groups.

这项研究确定蓝色或绿光的照射是否通过检查姐妹染色单体交换（SCE）频率（SCE）的外周淋巴细胞的频率（SCE）频率是否从五个具有DS的新生儿和五个核型正常的新生儿（对照）获得的外周淋巴细胞（对照）。用蓝色或绿色荧光光照射1、2、4或6小时，然后使用常规方法培养细胞周期中的淋巴细胞。我们的结果表明，尽管蓝光分别诱导了更多的SCE，但两组以剂量依赖性方式诱导每个细胞的诱导量增加。此外，在6h的蓝光照射后，DS组的网络诱导的SC比对照组中的SC高。

项目成果

N.Kamatani et al.: "Down syndrome with coexistent gout ; report of six patients and possible reasons for scarcity of descriptions of this association." Ann.Rheum.Dis.55. 649-650 (1997)

N.Kamatani 等人：“唐氏综合症与痛风并存；六名患者的报告以及缺乏这种关联描述的可能原因。”

Fang-yang Wu.: "SCE in the peripheral lymphocytes of newborns with Down syndrome after in vitro exposure to blue or green light" Mutation Research. 367. 261-264 (1996)

吴芳阳：“唐氏综合症新生儿体外暴露于蓝光或绿光后外周淋巴细胞的SCE”突变研究。

M.Oda et al.: "Effects of A-protomer and B-oligomer of pertussis toxin on murine immune response." Proc.Amer Soc.Microbiol.83-84 (1997)

M.Oda 等人：“百日咳毒素 A-原体和 B-寡聚体对小鼠免疫反应的影响。”

Kamatani,N.: "Down syndrome with coexistent gout" Ann.Rheum.Dis.55. 649-650 (1996)

Kamatani,N.：“唐氏综合症与痛风共存”Ann.Rheum.Dis.55。

M.Shimada et al.: "Development of sleep-wake rhythm in infants in NICU." J.Child Health. 57. 569-575 (1998)

M.Shimada 等人：“NICU 婴儿睡眠-觉醒节律的发展。”