Paleogenetics

古遗传学

• 批准号: 1000227705-2011
• 负责人: Poinar, Hendrik
• 金额: $ 1.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643183
• 关键词: Paleogenetics

We are developing a state-of-the-art facility, one of only a handful within Canada and North America, focused on the meticulous characterization of DNA and RNA from archival, forensic and fossil samples that span geologically significant time scales. This sequence data will be used to address a range of significant research themes including the evolution of pathogens particularly historically significant agents such as Black Death and HIV-1, that have altered the course of human history. We will use state of the art high throughput sequencing of DNA extracted from the arctic permafrost to map out bacterial, plant and animal communities across time, in the hope of understanding how climate change in the past effected their distribution and in turn aid us in thus developing a predictive model for monitoring impending change in a future warming Arctic. This has direct impact not only on the key animal and plant species currently living in the north, but the humans that depend upon them for their survival.

我们正在开发一个最先进的设施，这是加拿大和北部地区为数不多的设施之一 美国，专注于对跨越地质重要时间尺度的档案、法医和化石样本中的 DNA 和 RNA 进行细致的表征。该序列数据将用于解决一系列重要的研究主题，包括病原体的进化，特别是具有历史意义的病原体，例如黑死病和 HIV-1，它们改变了人类历史的进程。我们将使用最先进的高通量测序技术，对从北极永久冻土中提取的 DNA 进行测序，绘制不同时间段的细菌、植物和动物群落图，希望了解过去的气候变化如何影响它们的分布，从而帮助我们开发一个预测模型来监测未来北极变暖即将发生的变化。这不仅对目前生活在北方的主要动植物物种产生直接影响，而且对依赖它们生存的人类产生直接影响。