Total Synthesis of Novel Metabolites form Microorganisms

微生物新型代谢物的全合成

• 批准号: DP0449522
• 负责人: Prof Mark Rizzacasa
• 金额: $ 16.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-14 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0449522
• 关键词: Total; Synthesis; Novel; Metabolites; form

The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal metabolite zaragozic acid C.

该建议的主要目的是实现从微生物分离的许多生物活性的新型天然产物的化学合成。这将涉及到迄今为止开发的新方法以及改进的新方法。靶标将包括粘霉素鳄鱼蛋白A，B和D和Apicularen A，链霉菌代谢产物A和螺旋氟醇A和真菌代谢物ZaragozicC。